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Aberrant Complement Activation Is Associated With Structural Brain Damage in Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm
March 2025
Department of Neurology with Institute of Translational Neurology, University Hospital 4 Münster, Germany.
Background And Objectives: Levels of activated complement proteins in the CSF are increased in people with multiple sclerosis (MS) and are associated with clinical disease severity. In this study, we determined whether complement activation profiles track with quantitative MRI metrics and liquid biomarkers indicative of disease activity and progression.
Methods: Complement components and activation products (Factor H and I, C1q, C3, C4, C5, Ba, Bb, C3a, C4a, C5a, and sC5b-9) and liquid biomarkers (neurofilament light chain, glial fibrillary acidic protein [GFAP], CXCL-13, CXCL-9, and IL-12b) were quantified in the CSF of 112 patients with clinically isolated syndromes and 127 patients with MS; longitudinal MRIs according to a standardized protocol of the Swiss MS cohort were assessed.
Weeds and agro by-products for sustainable farming of edible field cricket, Gryllus madagascarensis (Orthoptera: Gryllidae).
PLoS One
January 2025
Department of Feed Development, Madagascar Biodiversity Center, Antananarivo, Madagascar.
Gryllus madagascarensis (Orthoptera: Gryllidae) is a cricket species that shows promise to mitigate food insecurity and malnutrition. But whether this species will accept low- to no-cost weeds and agro by-products as feed, and how these feeds affect its performance, remains unknown. This study assessed the acceptability of 66 weed species and agro by-products (derived from a single plant species) by adult G.
View Article and Find Full Text PDFThe posterior petroclinoid fold and petroclival ligament ossification patterns.
Surg Radiol Anat
January 2025
Department of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, 75 Mikras Asias str, Goudi, Athens, 11527, Greece.
Background: The skull base ligaments have been extensively studied in the literature due to their clinical and surgical significance. The posterior petroclinoid fold (PPCNF) and petroclival ligament (PCVL) are two adjacent structures that have barely been studied and are frequently confused. The present study uses an innovative classification system to investigate the PPCNF and PCVL ossification patterns.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
The University of Sydney, Sydney, NSW, Australia.
Background: Hyperphosphorylated tau (pTau) in Alzheimer's disease (AD) brain tissue is a complex mix of multiple tau species that are variably phosphorylated on up to 55 epitopes. Emerging studies suggest that phosphorylation of specific epitopes may alter the role of tau. The role of specific pTau species can be explored through protein interaction ("interactome") studies.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Kentucky, Lexington, KY, USA.
Background: Compared with the E3 allele of Apolipoprotein E (APOE), E4 increases late-onset Alzheimer's Disease (AD) risk up to 15-fold, while the E2 allele substantially decreases risk. In the CNS, ApoE is predominantly synthesized by astrocytes and microglia, making these two cell types promising targets for ApoE-directed therapeutic approaches. Our lab has generated an inducible "switch" mouse model (APOE4s2) in which we can conditionally replace E4 with the protective E2 in a cell-specific manner.
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