AI Article Synopsis
- The study investigated how age and timing of chelation therapy affect cadmium retention in rats of different ages (6, 11, 14 days old and 6 weeks old).
- Three chelating agents were tested, with MeOBDCG showing the greatest efficacy in reducing cadmium retention, particularly in older rats and with early administration.
- The liver retained the highest levels of cadmium, and the mobilized cadmium was primarily excreted through feces after treatment.
Article Abstract
In the present study the influence of age and time of chelation therapy on cadmium retention in 6-, 11-and 14-day-old rats and in 6-week-old rats has been investigated. Chelating agents N-benzyl-dithiocarboxy-D-glucamine (BDCG), sodium N-(metho-xybenzyl)-D-glucamine dithiocarbamate monohydrate (MeOBDCG) and N-methyl-N-dithiocarboxy-D-glucamine (MDCG) were administered intraperitoneally to three different groups at a dose of 1 mmol kg-1 body weight on two occasions following 115mCd intraperitoneal administration; immediately and after 24 h; after 24 h and 48 h; or after 48 h and 72 h. The 115mCd retention in the whole body and organs was determined 6 days after cadmium administration. Chelation therapy very effectively reduced cadmium retention in the whole body and organs, MeOBDCG being the most effective. The effects of chelating agents were significantly more pronounced in older than younger animals and in the case of early rather than late administration. The highest fraction of cadmium administered was retained in the liver, where also the strongest effect of chelation therapy was observed. Mobilized cadmium was excreted almost exclusively by the faecal route.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jat.2550110408 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of cadmium pathways in a high Cd accumulating cultivar versus a low Cd accumulating cultivar of Theobroma cacao L.
Plant Physiol Biochem
January 2025
Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, IRD, Université G. Eiffel, ISTerre, Grenoble, France. Electronic address:
Understanding cadmium (Cd) pathways in cacao trees is critical for developing Cd mitigation strategies. This study investigates whether Cd uptake and translocation mechanisms differ between a low and a high Cd-accumulating cacao cultivar. We sampled three replicate trees of each cultivar, and a grafted cultivar that shared the same scion as the low Cd accumulator but had a different rootstock.
View Article and Find Full Text PDFRegulation of anaplerotic enzymes by melatonin enhances resilience to cadmium toxicity in Vigna radiata (L.) R. Wilczek.
Plant Physiol Biochem
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Melatonin (Mel) is a tryptophan-derived (N-acetyl-5-methoxytryptamine) molecule. In the present study, role of Mel in the regulation of various anaplerotic enzymes is discussed in relation to N metabolism and H-ATPase activity in mung bean under Cd stress. The application of Mel to the Cd-stressed mung bean seedlings was remarkable in improving the activity of hexokinase (35.
View Article and Find Full Text PDFPhase transformation of calcium sulfate at mineral-solution interface: An overlooked pathway for selective enrichment of cadmium.
J Hazard Mater
January 2025
School of Metallurgy and Environment, Central South University, Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution, Changsha 410083, China; School of Environment and Energy, South China University of Technology, the Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters (Ministry of Education), Guangdong Engineering and Technology Research Center for Environmental Nanomaterials, Guangzhou 510006, China.
The reactions at the mineral-solution interface govern whether heavy metals (HMs) ions are retained within minerals or migrate with the solution, thus influencing their cycling and fate. However, the mechanisms driving this differential behavior of HMs at the interface remain poorly understood. In this study, we present a novel paradigm for the selective retention of HMs ions at the mineral-solution interface.
View Article and Find Full Text PDFThe Mechanisms of Cadmium Toxicity in Living Organisms.
Toxics
November 2024
UPIZ Educational and Research Laboratory of Biology-MF-NBU, New Bulgarian University, 1618 Sofia, Bulgaria.
Cadmium (Cd) is a toxic metal primarily found as a by-product of zinc production. Cd was a proven carcinogen, and exposure to this metal has been linked to various adverse health effects, which were first reported in the mid-19th century and thoroughly investigated by the 20th century. The toxicokinetics and dynamics of Cd reveal its propensity for long biological retention and predominant storage in soft tissues.
View Article and Find Full Text PDFSynergistic Remediation of Cadmium Pollution in Saline-Alkali Soil by Hydrogel and .
ACS Appl Mater Interfaces
January 2025
School of Chemistry and Materials Science, Ludong University, Yantai 264025, China.
The cadmium (Cd) in saline-alkali soil poses a serious threat to the ecological environment and human health. , as a hyperaccumulator plant, can remediate Cd in saline-alkali soil, but the efficiency of phytoremediation is low. To improve the remediation effect of Cd pollution in saline-alkali soil, this study for the first time uses the synergy of hydrogel and for the remediation of Cd in saline-alkali soil.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!