The crystal structure of recombinant rabbit interferon-gamma was solved by the multiple isomorphous replacement technique at 2.7-A resolution and refined to a crystallographic R-factor of 26.2%. The interferon crystallizes with one-half of the functional dimer in the asymmetric unit, with the two polypeptide chains of the dimer related by a crystallographic 2-fold symmetry axis. The structure is predominantly alpha-helical with extensive interdigitation of the alpha-helical segments of the two polypeptide chains.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
crystal structure
8
structure recombinant
8
recombinant rabbit
8
rabbit interferon-gamma
8
27-a resolution
8
polypeptide chains
8
interferon-gamma 27-a
4
resolution crystal
4
interferon-gamma solved
4
solved multiple
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!