BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. This manuscript details the process research and development efforts that enabled the synthesis of the phosphate salt of 1 on a multi-kilogram scale. Key considerations in the development of this process focused on safe execution and the requirement for telescoped synthetic transformations (i.e., without isolation of intermediate products) to contend with a lack of suitably crystalline products.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo9003508 | DOI Listing |
Publication Analysis
Top Keywords
process development
8
growth hormone
8
hormone secretagogue
8
secretagogue ghs
8
development tetrazole-based
4
tetrazole-based growth
4
ghs pharmaceutical
4
pharmaceutical development
4
development candidate
4
candidate bms-317180
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!