The meibomian glands, present within the tarsus, produce an oily fluid which is part of the tear film. The obstruction of this gland is common, and results in a meibomian cyst or chalazion. Initially, a chalazion may spontaneously resolve, or respond to conservative measures such as warm compresses and topical antibiotics. However, sometimes the lesion becomes persistent and prominent, leading to visual and aesthetic problems, requiring a surgical solution. We report a 23-year-old man, with a right lower eyelid chalazion, persisting for more than 1 year, refractory to local measures that was submitted to surgical correction via the subconjunctival approach. This report emphasizes the advantages of this technique, namely the fast and simple procedure, with an excellent cosmetic result.
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http://dx.doi.org/10.1080/14764170902902822 | DOI Listing |
Adv Mater
January 2025
Department of Chemical Engineering & Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.
Colloidal drug aggregates (CDAs) are challenging in drug discovery due to their unpredictable formation and interference with screening assays. These limitations are turned into a strategic advantage by leveraging CDAs as a drug delivery platform. This study explores the deliberate formation and stabilization of CDAs for local ocular drug delivery, using a modified smallmolecule glaucoma drug.
View Article and Find Full Text PDFArch Soc Esp Oftalmol (Engl Ed)
December 2024
Departamento de Oftalmología, Hospital Universitario Virgen de la Macarena, Sevilla, Spain; Miembros de la «Red de Enfermedades Inflamatorias, Enfermedades Inflamatorias Oculares, Enfermedades Inflamatorias No Infecciosas de la Superficie Ocular, Instituto de Salud Carlos III (RICORS). FISS-21-RD21/0002/0011»; Área de Oftalmología, Departamento de Cirugía, Universidad de Sevilla, Sevilla, Spain.
Although silicone oil is used as an intraocular buffer in vitreoretinal surgical procedures, its use can cause complications, including glaucoma. This study highlights the importance of individualized approaches for the management of silicone oil-induced glaucoma. A 62-year-old man with a past medical history of retinal detachment and multiple ocular surgical procedurespresented with uncontrolled ocular pressure peaks after retinal detachment surgery using silicone oil as a buffer, which did not resolve after removal of the buffer.
View Article and Find Full Text PDFJ Pharm Sci
December 2024
Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267. Electronic address:
Ocul Surf
October 2024
Department of Clinical Regenerative Medicine, Fujita Health University, Japan. Electronic address:
Purpose: This study explores the application of adipose-derived mesenchymal stromal cells (adMSCs) as a therapy for ocular inflammatory diseases utilizing a chronic GVHD model.
Methods: Human adMSCs were administered via subconjunctival injection into mice with chronic ocular GVHD. Clinical scores and changes in T cell populations were analyzed.
Cureus
October 2024
Oculoplastic, Orbital and Lacrimal Surgery, Aichi Medical University Hospital, Aichi, JPN.
Primary simple conjunctival cysts are congenital, non-neoplastic, fluid-filled lesions lined by non-keratinizing squamous epithelium without dermal appendages. They are usually located in the anterior superonasal or superotemporal orbit and are typically managed with complete surgical excision. A 69-year-old woman presented with a 10-month history of diplopia and a 2-week history of right lower eyelid swelling.
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