AI Article Synopsis
- Multiple myeloma (MM) shows a wide range of disease progression and survival, influenced by factors like age, performance status, and specific blood markers.
- Several models categorize patients into risk groups based on these factors to predict outcomes and guide treatment decisions.
- The International Staging System (ISS) is a widely used tool for prognosis but has limitations; incorporating serum free light chain ratios (sFLCR) and lactate dehydrogenase (LDH) might enhance its accuracy.
Article Abstract
Multiple myeloma (MM) patients have a highly variable disease course and survival varies from a few months to more than 10 years. Numerous prognostic factors have been identified, including age, performance status (PS), serum albumin, beta2-microglobulin (beta2M), lactate dehydrogenase (LDH), renal function, genetic factors, and serum free light chains (sFLCs) or their ratio (sFLCR). Several models have been built to separate patients into various risk groups with different outcomes. Staging systems need to be simple, accurate, and readily available in order to effectively guide treatment decisions now that effective treatments exist that prolong survival. The International Staging System (ISS) is currently in use; it is highly prognostic but presents some limitations. We suggest that the ISS prognostic potential could be improved with the addition of sFLCR and eventually LDH.
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| http://dx.doi.org/10.1053/j.seminhematol.2009.02.004 | DOI Listing |
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