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Survival Among Patients With ERBB2-Positive Metastatic Breast Cancer and Central Nervous System Disease.
JAMA Netw Open
January 2025
Department of Neurosurgery and Brain Metastasis Center, Memorial Sloan Kettering Cancer Center, New York, New York.
Importance: Approximately one-third of patients with ERBB2 (formerly HER2 or HER2/neu)-positive (ERBB2+) metastatic breast cancer (MBC) develop brain metastasis. It is unclear whether patients with disease limited to the central nervous system (CNS) have different outcomes and causes of death compared with those with concomitant extracranial metastasis.
Objective: To assess overall survival (OS) and CNS-related mortality among patients with ERBB2+ breast cancer and a diagnosis of CNS disease by disease distribution (CNS only vs CNS plus extracranial metastasis).
Comparison of surgical approaches and outcome for symptomatic pineal cysts: microscopic/endoscopic fenestration vs. stereotactic catheter implantation.
Acta Neurochir (Wien)
January 2025
Department of Neurosurgery, LMU University Hospital, Ludwig-Maximilians-University Munich, Marchioninistrasse 15, 81377, Munich, Germany.
Purpose: Treatment strategies for space-occupying/symptomatic pineal cysts (PC) are still up for debate. In this study we present PC management, outcome data and risk factors for recurrence after surgery, focusing on microscopic/endoscopic procedures vs. stereotactic catheter implantation as alternative treatment concept to permanently drain PC into ventricles/cisterns.
View Article and Find Full Text PDFIndividual management and prognostic assessment for long-term outcomes using a novel classification system of craniopharyngiomas: a retrospective study of single institution.
J Cancer Res Clin Oncol
January 2025
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Purpose: This study aims to propose a classification system to more accurately understand the features and nature of different CPs, to investigate the correlation between different topographies of CPs and their surgical outcomes.
Methods: A retrospective analysis was conducted on 91 surgically resected CPs. They were categorized into six types based on their location and origin.
IRS2 as a driver of brain metastasis in colorectal cancer: a potential target for novel therapeutic strategies.
Neuro Oncol
January 2025
Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Background: Colorectal cancer (CRC) ranks as the fourth most common cause of brain metastasis (BM), with its incidence on the rise. However, the molecular mechanisms driving the formation of these lesions from CRC remain unclear.
Methods: We analyzed the FoundationOne genomic database, which includes over 35,000 CRC samples from both local and metastatic sites.
[Exercise therapy in outpatient rehabilitation programmes for patients with comorbid digestive pathology in colon cancer and chronic pancreatitis. (Open randomized controlled trial)].
Vopr Kurortol Fizioter Lech Fiz Kult
January 2025
Federal Centre for Brain and Neurotechnology of Federal Medical and Biological Agency, Moscow, Russia.
Unlabelled: Sanogenetic effects of physical factors that have an activating effect on the adaptation-compensatory mechanisms of the body are known. On the other hand, their comparative effect on the pathogenetic links of the disease has been proven. It is advisable to use them in comorbid pathology of the digestive system to increase the effectiveness of rehabilitation measures.
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