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Metabolic labeling of sialic acids in living animals with alkynyl sugars. | LitMetric

Metabolic labeling of sialic acids in living animals with alkynyl sugars.

Angew Chem Int Ed Engl

Department of Chemistry and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

Published: June 2009

Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868584PMC
http://dx.doi.org/10.1002/anie.200806319DOI Listing

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