Arthritis of the basal joint of the thumb is a condition that is becoming even more common as longevity increases and more people have active lifestyles in later life. The role of new hyaluronase-based injectable agents is evolving. A number of surgical procedures are effective in treating early-stage arthritis; the commonly performed trapezium resection and ligament reconstruction procedures have been modified by using limited-incision approaches, arthroscopic assistance, and bioengineered materials, as well as metacarpal repositioning osteotomy.
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INhibitor of Growth (ING1-5) proteins are epigenetic readers that target histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes to the H3K4Me3 mark of active transcription. ING5 targets Moz/Morf and HBO1 HAT complexes that alter acetylation of H3 and H4 core histones, affecting gene expression. Previous experiments in vitro indicated that ING5 functions to maintain stem cell character in normal and in cancer stem cells.
View Article and Find Full Text PDFJ Hand Surg Glob Online
May 2024
Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
Purpose: Thumb basal joint arthroplasty (BJA) performed for thumb basal joint arthritis is associated with high patient satisfaction. However, complications requiring reoperation occur, with a previously reported early reoperation rate (within 2 years) of 1.5%.
View Article and Find Full Text PDFFront Vet Sci
December 2024
Zhanjiang Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, China.
Introduction: Rumen-protected fat (RPF) is a vital dietary energy source for dairy cows. However, the influences of RPF on rumen volatile fatty acid (VFA) content and bacterial communities in goats are poorly documented.
Methods: In this study, 12 castrated male goats (body weight [BW]: 13.
Front Endocrinol (Lausanne)
January 2025
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Background: Evidence indicates a negative link between glucosamine and age-related cognitive decline and sarcopenia. However, the causal relationship remains uncertain. This study aims to verify whether glucosamine is causally associated with cognitive function and sarcopenia.
View Article and Find Full Text PDFFish Physiol Biochem
January 2025
Key Laboratory for Animal Nutrition and Feed Science of Hubei Province, Wuhan Polytechnic University, Wuhan, 430000, China.
Hydroxycinnamic acid derivatives are a class of phenolic acid compounds, including sinapic acid, ferulic acid, and caffeic acid, which are widely found in plants. This experiment was conducted to study the effects of hydroxycinnamic acid derivatives (sinapic acid, ferulic acid, and caffeic acid) on the growth performance, muscle physical parameters, and intestinal morphology of tilapia. A total of 320 tilapia fingerlings (9.
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