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Socio-demographic and clinical determinants of self-care in adults with type 2 diabetes: a multicenter cross-sectional study in Zhejiang province, China.
BMC Public Health
January 2025
Department of Endocrinology, Lishui People's Hospital, Lishui, Zhejiang, China.
Background: Self-care, a process of maintaining health through health-promoting practices and managing illness, is pivotal for the management of type 2 diabetes. This study aimed to explore the self-care level and investigate its socio-demographic and clinical determinants among Chinese adults with type 2 diabetes.
Methods: In this multicenter cross-sectional study, we enrolled 495 Chinese adults with type 2 diabetes from the outpatient departments of three tertiary hospitals in Zhejiang province, China.
Background: Transoral outlet reduction endoscopy (TORe) and glucagon-like peptide-1 agonist, liraglutide, have individually shown promise in managing weight regain after Roux-en-Y gastric bypass. However, combined effects of adjunctive liraglutide to TORe remain unexplored. A cross-over design was utilized to evaluate the efficacy of liraglutide treatment when initiated immediately post-TORe or 1 year post-TORe.
View Article and Find Full Text PDFEffects of fluconazole and amphotericin B in the control of cryptococcal pneumonia in vivo.
AMB Express
January 2025
Department of Respiratory and Critical Care, Haining Branch, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Cryptococcal pneumonia is a severe fungal infection of the respiratory system, predominantly caused by Cryptococcus neoformans. Its incidence is increasing, driven by evolving pathogen dynamics and heightened susceptibility among patient populations. This investigation aimed to assess the combined therapeutic efficacy of Fluconazole and Amphotericin B for cryptococcal pneumonia and to explore the roles of miR-15b and TGF-β1 in modulating treatment response.
View Article and Find Full Text PDFA simple approach to fabricate chitosan-delivered avermectin controlled release microparticles for improved efficacy and reduced residues.
Int J Biol Macromol
January 2025
College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, Shandong, PR China. Electronic address:
The presence of a synergistic effect between carrier and insecticide in controlled release formulations is highly desirable to improve efficacy to target pests and reduce insecticide use. Herein, controlled release microparticles of avermectin (AVM) were fabricated using natural chitosan (CTS) as a carrier by a pH adjustment method. The resulted AVM@CTS microparticles displayed high encapsulation efficiency (73.
View Article and Find Full Text PDFNanoparticle-based Drug Delivery Systems to Modulate Tumor Immune Response for Glioblastoma Treatment.
Acta Biomater
January 2025
School of Materials and Energy, Southwest University, Chongqing 400715, China; Yibin Academy of Southwest University, Yibin 644005, China. Electronic address:
Glioblastoma (GBM) is a primary central nervous system neoplasm, characterized by a grim prognosis and low survival rates. This unfavorable therapeutic outcome is partially attributed to the inadequate immune infiltration and an immunosuppressive microenvironment, which compromises the effectiveness of conventional radiotherapy and chemotherapy. To this end, precise modulation of cellular dynamics in the immune system has emerged as a promising approach for therapeutic intervention.
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