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Aim: To study the contribution of the Ala54Thr genetic polymorphism of the gene to the risk of developing type 2 diabetes mellitus among the Yakut population.
Materials And Methods: The study included participants who filled out a questionnaire approved by the Local Committee on Biomedical Ethics at the Yakut Science Centre of complex medical problems and voluntarily signed an informed consent to conduct a genetic study. The sample consisted of 181 patients of the endocrinological department of the Republican Hospital No.
Genetic polymorphism of fatty acid binding protein-2 in hyperlipidemic Asian Indians in North India.
Am J Hum Biol
March 2023
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- - The study investigates the Ala54Thr polymorphism of the FABP-2 gene, which is connected to lipid metabolism, particularly focusing on its impact on triglyceride levels in hyperlipidemic Asian Indians from North India.
- - By analyzing groups of hyperlipidemic and normolipidemic individuals, the research found no significant differences in the distribution of the Ala54Thr genotypes between the two groups, but the heterozygous genotype was linked to higher triglyceride and VLDL levels.
- - Ultimately, the findings suggest that the heterozygous FABP-2 Ala54Thr genotype could be a contributing risk factor for hypertriglyceridemia among this population.
Polymorphism in Apolipoprotein C3 (APOC3) and Fatty Acid-Binding Proteins (FABP2) Genes in Nondiabetic Dyslipidemic Patients: A Tertiary Care Hospital-Based Pilot Study.
J Lab Physicians
June 2022
Department of Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Article Synopsis
- Dyslipidemia is linked to coronary heart disease (CHD) and is particularly prevalent in individuals with diabetes; however, non-diabetic dyslipidemics (NDD) are often overlooked for CHD risk.
- This pilot study investigates the genetic factors influencing lipid metabolism, focusing on the relationship between two specific genetic polymorphisms (FABP2-Ala54Thr and APOC3-rs5128) and the risk of dyslipidemia and CHD in NDD.
- The study analyzed 90 participants, revealing a significant association between the APOC3 polymorphism and dyslipidemia, while the FABP2 polymorphism showed no such correlation, indicating that genetic predispositions can affect lipid levels and potential health outcomes
Ala54Thr Polymorphism and Post-Training Changes of Body Composition and Biochemical Parameters in Caucasian Women.
Genes (Basel)
June 2021
Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland.
The functional Ala54Thr polymorphism (rs1799883) is strongly associated with lipid and carbohydrate metabolism, although the function of its potential modifying effect on training-induced changes in obesity-related parameters is still unknown. The aim of the present study was to investigate the influence of the Ala54Thr polymorphism on post-training changes of selected body mass and body composition measurements, as well as with biochemical parameters of energy metabolism. Accordingly, alleles and genotypes distribution in a group of 168 young, nonobese Caucasian women measured for chosen body composition parameters, lipid profile, and glucose levels before and after the completion of a 12-week aerobic training program were studied.
View Article and Find Full Text PDFAssociation between the FABP2 Ala54Thr and CRP+1059C/G polymorphisms and small dense LDL level in patients with atherosclerosis: a case-control study.
Arch Physiol Biochem
February 2023
Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Background: The polymorphisms of fatty acid-binding protein 2 (FABP2) and C-reactive protein (CRP) might act as genetic risk factors for atherosclerosis. The study aimed to investigate the relationship between FABP2 Ala54Thr and CRP+1059C/G polymorphisms and atherosclerosis as well as the association of Small dense-LDL (sd-LDL).
Methods: A total of 255 subjects (125 controls and 130 patients) were included.
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