AI Article Synopsis
- The study explored the relationship between oxidative stress, HIF-1 alpha, and acute hypoxic ventilatory response (AHVR) after hypoxic training in elite runners.
- Six elite runners underwent "living high-training low" (LHTL) for 18 days, with measurements of AHVR and various oxidative stress markers taken before and after the training.
- Results showed that LHTL improved AHVR and increased HIF-1 alpha mRNA sensitivity, indicating oxidative stress may play a role in how athletes adapt to hypoxic conditions.
Article Abstract
We investigated the strength of the association between oxidative stress, hypoxia inducible factor 1 (HIF-1 alpha) and acute hypoxic ventilatory response (AHVR) after hypoxic training in elite runners. Six elite runners were submitted to 18-day of "living high-training low" (LHTL) and six performed the same training in normoxia. AHVR was measured during an acute hypoxic test before and after training. Plasma levels of protein oxidation (AOPP), malondialdehydes and (HIF-1 alpha) mRNA in the leukocytes were measured before and after the acute hypoxic test. LHTL increased AHVR and amplified the responses of HIF-1 alpha mRNA and AOPP (Delta(AOPP)) to the acute hypoxic test. Furthermore, between PRE and POST, the changes in Delta(AOPP) were correlated with the changes in AHVR (r=0.69, P=0.01). The ventilatory acclimatization to hypoxia occurring in athletes after LHTL seems to be modulated by oxidative stress. Furthermore, LHTL induced a higher sensitivity of HIF-1 alpha mRNA to acute hypoxia in elite athletes.
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| http://dx.doi.org/10.1016/j.resp.2009.04.012 | DOI Listing |
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