Forty-seven patients including 18 with renal failure were studied. Kidney length, degree of cortical echogenicity, parenchymal thickness, visibility and dimensions of renal papillae, and existence of renal cysts were recorded during abdominal ultrasound investigations in all patients. Indications and contraindications for renal biopsy were determined. Ultrasound is a valuable method of easy evaluation of indications for renal biopsy in patients with renal failure. This method avoids the risks of postbiopsy complications, drug overdosage as well as additional X-ray exposures and scintigrams.
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http://dx.doi.org/10.1007/BF02549612 | DOI Listing |
Physiol Rep
February 2025
Department of Molecular Medicine and Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Chronic kidney disease is a life-threatening disease worldwide. PPARα is a crucial transcriptional regulator of lipid metabolism and inflammation. Here, we examine whether a novel selective PPARα modulator, pemafibrate modulates renal injury in a model of unilateral ureteral obstruction (UUO).
View Article and Find Full Text PDFJ Biochem Mol Toxicol
February 2025
Calcium Signaling Laboratory, Veterans Affairs Medical Center, Research Service, Washington, District of Columbia, USA.
Crystalline nephropathy (CN) is characterized by deposition of microcrystals within the kidney tubular microstructure, specifically in the renal tubular cells. Nephropathic conditions have been observed in kidney stone patients as nephrocalcinosis, resulting from the deposition of calcium phosphate (CaP) microcrystals mainly within the renal tubule. CaP microcrystals trigger nephrotoxicity and cell death leading to acute and chronic kidney disease and in some cases end stage renal disease.
View Article and Find Full Text PDFFASEB J
February 2025
Department of Kidney Transplantation, Nephropathy Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Renal ischemia-reperfusion injury (IRI) is a prevalent cause of acute kidney injury, however, the regulatory mechanisms of miR-374b-5p in renal IRI remain poorly understood. We established hypoxia/reoxidation (H/R)-induced renal injury models using HK-2 and TCMK-1 cells, as well as an ischemia-reperfusion (I/R)-induced mouse model. Renal tubular epithelial cells (RTECs) viability and apoptosis were assessed using CCK-8, flow cytometry, and TUNEL assays.
View Article and Find Full Text PDFIndian J Urol
January 2025
Department of Urology, Cancer Institute of the State of São Paulo, São Paulo, Brazil.
Purpose: This study aims to assess the impact of unclassified renal cell carcinoma (uRCC) on clinical, pathological, and oncological outcomes compared with clear cell renal cell carcinoma (ccRCC).
Materials And Methods: We analyzed the data of 48 uRCC and 688 ccRCC cases, collected from a histopathological database at a single center from July 2011 to August 2019. uRCC cases were confirmed according to the 2016 World Health Organization classification.
J Glob Infect Dis
December 2024
Department of Nephrology, Christian Medical College, Vellore, Tamil Nadu, India.
Introduction: The aim of the study was to study the clinical profile and outcomes of nocardiosis in renal allograft recipients.
Methods: This was a retrospective study of clinical outcomes in consecutive renal allograft recipients with infection over a 22-year period (2000-2022) from a tertiary care center in Southern India. The clinical data were obtained from electronic medical records and patient files.
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