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Mediating roles of social support in lives of men who have sex with men living with HIV.
Health Psychol
March 2025
Center of Population Sciences for Health Equity, College of Nursing, Florida State University.
Objectives: This study examined the mediating role of social support between distal minority stressors, psychological states, and health-related quality of life (HRQoL) among men who have sex with men (MSM) living with HIV in the United States. We also investigated the role of social support in the relationship between resilient coping and mental HRQoL.
Method: A prospective cohort of 263 MSM living with HIV consisted of 25.
Effect of sotagliflozin on major adverse cardiovascular events: a prespecified secondary analysis of the SCORED randomised trial.
Lancet Diabetes Endocrinol
February 2025
Université Paris-Cité, INSERM U1148 and AP-HP Hôpital Bichat, Paris, France; French Alliance for Cardiovascular Trials, Paris, France.
Background: Sodium-glucose co-transporter (SGLT)-2 inhibitors have shown consistent benefit in improving heart failure-related outcomes but not ischaemic cardiovascular events such as myocardial infarction or stroke. We assessed if the dual SGLT1/2 inhibitor sotagliflozin improves ischaemic outcomes.
Methods: We did a prespecified secondary analysis of the SCORED trial, which was a double-blind, placebo-controlled, randomised clinical trial enrolling patients (aged ≥18 years) with type 2 diabetes, chronic kidney disease (estimated glomerular filtration rate [eGFR] 25-60 mL/min per 1·73 m), and additional cardiovascular risk factors.
Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma.
Sci Rep
February 2025
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, CLS-11090, Boston, MA, 02115, USA.
Alterations in protein glycosylation are observed in many solid tumor types leading to formation of tumor-associated carbohydrate antigens (TACAs). The most common TACA is the Tn antigen (CD175), which is a mucin-type O-GalNAc-Ser/Thr/Tyr glycan in membrane and secreted glycoproteins. In addition, two other TACAs are CA19-9 (sialyl-Lewis a), which is used as a prognostic serum marker for pancreatic cancer, and its isomer sialyl-Lewis x (SLex, CD15s), which is overexpressed in many cancer types and associated with metastasis.
View Article and Find Full Text PDFVariation of Stomach Shapes in Gastric Emptying Scintigraphy: Correlation With Gastric Emptying Results, Body Weight, and Symptoms.
Neurogastroenterol Motil
February 2025
Section of Gastroenterology, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Article Synopsis
- This study aimed to explore how different stomach shapes observed in gastric emptying scintigraphy (GES) relate to gastric emptying speeds, body weight, and GI symptoms.
- Researchers reviewed 397 GES studies, identifying five stomach shapes: crescentic, J-shaped, reversed-L, cylindrical, and bag-like, with crescentic being the most common.
- Findings revealed that crescentic stomachs had the highest body mass index (BMI), while bag-like stomachs showed the slowest gastric emptying and more severe regurgitation and heartburn symptoms.
Carbohydrate antigens Lewis a and Lewis b act as tumor markers cooperating with CA19.9 in the management of PDAC patients.
Clin Chim Acta
January 2025
Dipartimento di Medicina e Chirurgia, University of Insubria, Varese, Italy. Electronic address:
Background: CA19.9 is the unique marker recommended for the preoperative staging and the follow-up of patients suffering from pancreatic ductal adenocarcinoma (PDAC) but up to 30% of PDAC patients maintain normal CA19.9 values and cannot be monitored in this way.
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