Recent reviews of recognition receiver operating characteristics (ROCs) claim that their curvilinear shape rules out threshold models of recognition. However, the shape of ROCs based on confidence ratings is not diagnostic to refute threshold models, whereas ROCs based on experimental bias manipulations are. Also, fitting predicted frequencies to actual data is a more sensitive method for model comparisons than ROC regressions. In a reanalysis of 59 published data sets, the 2-high-threshold model (2HTM) fit the data better than an unequal variance signal detection model in about half of the cases. Three recognition experiments with experimental bias manipulation were conducted that yielded linear ROCs and a better fit of the 2HTM in all cases. On the basis of actual data and a simulation, the authors argue that both models are at least equally valid as measurement tools and can perhaps be integrated theoretically.
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http://dx.doi.org/10.1037/a0015279 | DOI Listing |
JB JS Open Access
January 2025
School of Medicine, Rural Clinical School, University of Queensland, Toowoomba, Queensland, Australia.
Background: Although there is a known correlation between obesity and revision risk following total knee arthroplasty (TKA), there is an ongoing debate regarding the appropriateness of denying TKA solely based on the body mass index (BMI) of a patient. Our aim was to determine whether a patient's American Society of Anesthesiologists (ASA) class predicts their risks of early all-cause revision and revision for periprosthetic joint infection (PJI) following primary TKA, independent of their BMI.
Methods: Data from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) were obtained regarding all patients who underwent primary TKA for osteoarthritis in Australia from January 1, 2015, to December 31, 2022.
Front Pharmacol
January 2025
Department of Oncology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Objective: The combination of pembrolizumab and chemotherapy has demonstrated notable clinical advantages in improving overall survival than chemotherapy alone for patients with untreated advanced pleural mesothelioma. The purpose of this study was to assess its cost-effectiveness.
Materials And Methods: A Markov state-transition model was constructed using data from the IND227 phase 3 randomized clinical trial.
Front Pharmacol
January 2025
Health Economics Unit, School of Public Health, University of Cape Town, Cape Town, South Africa.
Background: The treatment of chronic myeloid leukemia through tyrosine kinase inhibitors (TKIs) has achieved promising efficacy and safety outcomes, however the costs are associated with a substantial economic burden. The objective of this study was to develop a Markov model with a 20-year time horizon to assess the cost effectiveness of TKIs from a public healthcare system perspective in South Africa.
Methods: We constructed a Markov model to compare three strategies in which treatment was initiated with either imatinib, nilotinib, or dasatinib.
Front Oncol
January 2025
Department of Breast and Thyroid Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China.
Background: Breast conserving surgery (BCS) is a standard treatment for breast cancer. Intraoperative frozen section analysis (FSA) is widely used for margin assessment in BCS. In addition, FSA-assisted excisional biopsy is still commonly practiced in many developing countries.
View Article and Find Full Text PDFAm J Clin Exp Urol
December 2024
Division of Urology, Department of Surgery, School of Medicine, University of Maryland Baltimore, MD, USA.
Purpose: The estimated glomerular filtration rate (eGFR) has historically been calculated with a race-coefficient multiplier (RCM); however, the RCM has been broadly criticized as inaccurate and a potential contributor to exacerbating disparities. We evaluated the impact of the RCM on eGFR and examined the 30-day post-cystectomy complications in a muscle-invasive bladder cancer cohort.
Materials And Methods: We retrospectively analyzed patients diagnosed with MIBC who underwent cystectomy in the ACS NSQIP database from 2006 to 2020 using CPT and ICD codes.
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