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The potential effect of d-cycloserine on the development of anxiety during exposure sessions in patients with agoraphobia.
J Psychiatr Res
October 2024
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences, Campus Charité Mitte, Germany. Electronic address:
Article Synopsis
- The study investigates the impact of d-cycloserine (DCS) on anxiety levels during exposure therapy for patients with agoraphobia compared to a placebo group.
- A total of 73 patients underwent cognitive behavioral therapy with exposure sessions, with the DCS group showing reduced anxiety levels over time while the placebo group exhibited stable anxiety.
- Results indicate that DCS may have short-term benefits in managing anxiety during treatment, but further confirmatory research is necessary to validate these findings.
Panic-agoraphobic symptoms in adults with ASD: the role of ruminative thinking and inflexibility.
CNS Spectr
May 2024
Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Pisa, Italy.
Background: Scientific literature has highlighted the link between autism spectrum disorder (ASD) and anxiety disorders, but few studies have delved into the relationship between ASD and panic-agoraphobic disorders. The aim of this study is to investigate the relationship between autism spectrum and panic-agoraphobic symptoms, examining whether and which autistic domains are predictive of the presence of specific panic-agoraphobic symptoms.
Materials And Methods: Forty-five adult subjects with ASD and 50 healthy controls (HCs) were evaluated through the Structured Clinical Interview for DSM-5, Research Version and assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Panic-Agoraphobic - Short Version (PAS-SV) questionnaires.
Evaluation of effect of brief-intensive cognitive behavior therapy on symptoms severity in relation with catastrophic cognition in patients with panic disorder: a randomized controlled trial.
Curr Med Res Opin
April 2024
Psychiatry Unit, Department of Medicine, College of Medicine, University of Duhok, Duhok City, Iraq.
Introduction: Due to a dearth of evidence, we examined the effectiveness of brief-intensive CBT on symptom severity and catastrophic cognition in patients with panic disorder (PD).
Materials And Methods: In this randomized controlled trial, 155 patients were assigned to either the experimental group (2 successive days of brief-intensive CBT-3 h per day) or the control group (regular pharmacotherapy only). After excluding ineligible participants, 20 patients in the brief intensive CBT group and 18 patients in the control group completed the study and were included in the final analysis.
Brief scales for the measurement of target variables and processes of change in cognitive behaviour therapy for major depression, panic disorder and social anxiety disorder.
Behav Cogn Psychother
July 2024
Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Background: The measurement of process variables derived from cognitive behavioural theory can aid treatment development and support the clinician in following treatment progress. Self-report process measures are ideally brief, which reduces the burden on patients and facilitates the implementation of repeated measurements.
Aims: To develop 13 brief versions (3-6 items) of existing cognitive behavioural process scales for three common mental disorders: major depression, panic disorder, and social anxiety disorder.
CBT-Intervention for panic disorder in primary care: 5 years follow-up of a cRCT during the Covid-19 pandemic.
PLoS One
July 2023
Institute of General Practice and Family Medicine, University Hospital, LMU Munich, Munich, Germany.
A practice team-based exercise programme with elements of cognitive behavioural therapy (CBT) and case management for patients with panic disorder with or without agoraphobia in primary care showed significant positive effects. Here, we analyse the long-term effects (>5 years) of this intervention in the stressful context of the Covid-19 pandemic. All participants of the original PARADIES cluster randomized controlled trial (cRCT; 2012-2016) were invited to participate in a follow-up during the Covid-19 pandemic.
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