Computer supported treatment planning systems aim at predicting treatment results. Recently attacked challenges base not only on anatomical findings, but include physiological processes. This way, interventions which are highly depending on patient physiology become predictable and can be supported in computer based planning. Though the necessity to validate computations used for treatment planning is unquestioned available models lack validation. This contribution discusses challenges for designing a validation study for the example intervention of radiofrequency ablation (RFA) in the liver.
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