Antibody-mediated immunity is generally accepted to be a major cause of kidney allograft injury and loss. Post-transplantation monitoring for circulating alloantibodies was proposed to represent a useful noninvasive diagnostic approach to assess individual immunologic risks and to guide the implementation of specific therapeutic measures. This was supported by the recent establishment of highly sensitive and specific solid phase immunoassays for detailed characterisation of reactivity patterns. Nevertheless, imperfect associations of serologic results with biopsy-based criteria of antibody-mediated rejection, as well as the disputed long-term significance of circulating alloantibody detected in recipients with normal graft function, necessitate a careful interpretation of monitoring results.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.humimm.2009.04.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
White Fluorescent Carbon Dots for Specific Fe3+ Detection and Imaging Applications.
Chem Asian J
January 2025
University of Macau, Institute of Applied Physics and Materials Engineering, MACAO.
In recent years, carbon dots (CDs) with fluorescence imaging function have been widely used in biomedicine, electronic manufacturing and environmental monitoring. However, monochromatic fluorescence is often limited by the application environment and loses its effectiveness. Here, we carefully designed white fluorescent CDs (WF-CDs) by solvothermal method, which is used for fluorescence imaging applications under different environmental conditions.
View Article and Find Full Text PDFBisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
J Agric Food Chem
January 2025
Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan.
Curcuminoids, found in turmeric ( L.), include curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Although CUR and DMC are well-studied, the anti-inflammatory effects of BDMC remain less explored.
View Article and Find Full Text PDFRole of artificial intelligence in predicting disease-related malnutrition - A narrative review.
Nutr Hosp
January 2025
Centro de Investigación de Endocrinología y Nutrición. Universidad de Valladolid.
Background: disease-related malnutrition (DRM) affects 30-50 % of hospitalized patients and is often underdiagnosed, increasing risks of complications and healthcare costs. Traditional DRM detection has relied on manual methods that lack accuracy and efficiency.
Objective: this narrative review explores how artificial intelligence (AI), specifically machine learning (ML) and deep learning (DL), can transform the prediction and management of DRM in clinical settings.
Novel perspectives on the pharmacological treatment of thyroid-associated ophthalmopathy.
Front Endocrinol (Lausanne)
January 2025
No. 1 Teaching Hospital, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China.
Thyroid-associated ophthalmopathy (TAO), an autoimmune disease closely related to thyroid dysfunction, remains a challenging ophthalmic condition among adults. Its clinical manifestations are complex and diverse, and disease progression can lead to exophthalmos, diplopia, exposure keratitis, corneal ulceration, and compressive optic neuropathy, resulting in irreversible vision damage or even blindness. Traditional treatment methods for TAO, including glucocorticoids, immunosuppressants, and radiation therapy, often have limitations and side effects, making this disease problematic in ophthalmology.
View Article and Find Full Text PDFPotential therapeutic strategies for MASH: from preclinical to clinical development.
Life Metab
October 2024
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Current treatment paradigms for metabolic dysfunction-associated steatohepatitis (MASH) are based primarily on dietary restrictions and the use of existing drugs, including anti-diabetic and anti-obesity medications. Given the limited number of approved drugs specifically for MASH, recent efforts have focused on promising strategies that specifically target hepatic lipid metabolism, inflammation, fibrosis, or a combination of these processes. In this review, we examined the pathophysiology underlying the development of MASH in relation to recent advances in effective MASH therapy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!