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Resistance of to Trimethoprim: Insights into Genes Encoding Dihydrofolate Reductase, Thymidylate Synthase and Serine Hydroxymethyltransferase in the Rickettsiales.
Insects
December 2024
Department of Entomology, University of Minnesota, St. Paul, MN 55108, USA.
Bacterial and eukaryotic dihydrofolate reductase (DHFR) enzymes are essential for DNA synthesis and are differentially sensitive to the competitive inhibitors trimethoprim and methotrexate. Unexpectedly, trimethoprim did not reduce abundance, and the Stri DHFR homolog contained amino acid substitutions associated with trimethoprim resistance in . A phylogenetic tree showed good association of DHFR protein sequences with supergroup A and B assignments.
View Article and Find Full Text PDFMolecular survey of vector-borne agents in lowland tapirs (Tapirus terrestris) from Brazil reveals a new Anaplasma genotype.
Acta Trop
December 2024
Vector-Borne Bioagents Laboratory (VBBL), Faculdade de Ciências Agrárias e Veterinárias (FCAV), Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) - Jaboticabal, São Paulo, Brazil. Electronic address:
Although vector-borne agents have been detected in different species of wild animals, studies involving tapirs (Tapirus terrestris), the largest land mammals in Brazil, are scarce. The aim of the present study was to investigate the occurrence and molecular identity of Anaplasmataceae agents, Coxiella burnetii and Hepatozoon spp. in blood samples of wild T.
View Article and Find Full Text PDFA Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis.
Vet Sci
October 2024
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Article Synopsis
- * Current treatments primarily focus on managing symptoms, including restoring fluid levels and preventing serious complications like laminitis and sepsis.
- * Ion channels in the intestines play a crucial role in controlling fluid and electrolyte movement, and there is potential for future treatments targeting these channels to help manage diarrhea related to equine colitis.
Significance of Anaplasma phagocytophilum, Babesia caballi, and Theileria equi as etiologic agents in horses with clinical manifestations from the metropolitan area of Rio De Janeiro, Brazil.
Trop Anim Health Prod
September 2024
Department of Veterinary Medicine and Surgery, Federal Rural University of Rio de Janeiro (UFRRJ), Seropédica, Rio de Janeiro, Brazil.
Equine Piroplasmosis (EP) and Equine Granulocytic Anaplasmosis (EGA) are diseases that affect horses, transmitted by ixodid ticks, causing a nonspecific febrile syndrome. Equine Piroplasmosis is endemic in Brazil, and most horses are in enzootic stability. Serological and molecular studies carried out on horses in Brazil have shown the presence of Anaplasma phagocytophilum, however, the clinical relevance of this infection has not yet been established.
View Article and Find Full Text PDFDiversity of spp., spp. and spp. in vampire bats.
Curr Res Parasitol Vector Borne Dis
May 2024
Vector-Borne Bioagents Laboratory (VBBL), Department of Pathology, Reproduction and One Health, School of Agricultural and Veterinarian Sciences, São Paulo State University (Unesp), Jaboticabal, 14884-900, SP, Brazil.
Although bats (Mammalia: Chiroptera) act as natural reservoirs for many zoonotic pathogens around the world, few studies have investigated the occurrence of agents in bats, especially vampire bats. The family (order Rickettsiales) encompasses obligate intracellular bacteria of the genera , , , , , and . The present study aimed to investigate, using molecular techniques, the presence of species of , , and in vampire bats sampled in northern Brazil.
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