Screening for preinvasive disease of the cervix, and detecting and mapping the lesions for treatment, are fundamental to programs for the prevention of cervical cancer. These will become even more important in women vaccinated against humanpapilloma viruses 16 and 18. Biophysical imaging technologies have considerable potential advantages in both screening for and mapping the lesions. This review describes the technologies that seem to have the greatest promise.
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http://dx.doi.org/10.2217/fon.09.5 | DOI Listing |
Brain Sci
December 2024
Neuroinformatics Laboratory (NiLab), Bruno Kessler Foundation (FBK), 39123 Trento, Italy.
In glioma surgery, maximizing the extent of resection while preserving cognitive functions requires an understanding of the unique architecture of the white matter (WM) pathways of the single patient and of their spatial relationship with the tumor. Tractography enables the reconstruction of WM pathways, and bundle segmentation allows the identification of critical connections for functional preservation. This study evaluates the effectiveness of a streamline-based approach for bundle segmentation on a clinical dataset as compared to the traditional ROI-based approach.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Neurosurgery, Department of Neuroscience, Psychology, Pharmacology and Child Health, University Hospital of Careggi, University of Florence, 50134 Florence, Italy.
Navigated transcranial magnetic stimulation (nTMS) has seldom been used to study visuospatial (VS) circuits so far. Our work studied (I) VS functions in neurosurgical oncological patients by using repetitive nTMS (rnTMS), (II) the possible subcortical circuits underneath, and (III) the correspondence between nTMS and direct cortical stimulation (DCS) during awake procedures. We designed a monocentric prospective study, adopting a protocol to use rnTMS for preoperative planning, including VS functions for lesions potentially involving the VS network, including neurosurgical awake and asleep procedures.
View Article and Find Full Text PDFTo myelinate axons, oligodendrocyte precursor cells (OPCs) must stop dividing and differentiate into premyelinating oligodendrocytes (preOLs). PreOLs are thought to survey and begin ensheathing nearby axons, and their maturation is often stalled at human demyelinating lesions. Lack of genetic tools to visualize and manipulate preOLs has left this critical differentiation stage woefully understudied.
View Article and Find Full Text PDFRadiol Phys Technol
January 2025
Department of Diagnostic Imaging, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Stroke
January 2025
South Western Sydney Clinical School University of New South Wales, Department of Neurology Liverpool Hospital, Ingham Institute of Applied Medical Research, Australia (C.C., L.L., M.P.).
Background: Vascular territory mapping (VTM) software estimates which intracerebral vessel provides predominant arterial flow to a brain voxel. The presence of antegrade flow in the setting of acute middle cerebral artery (MCA) occlusion is associated with improved outcomes. We identify whether VTM software is a determinant of antegrade flow in patients with proximal MCA occlusion.
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