Tubercular meningitis is one of the serious manifestations of tuberculosis. It remains a significant contributor to the morbidity and mortality in children. Meningeal involvement in tuberculosis is detected by physical, chemical and cytological examination of cerebrospinal fluid (CSF). The cytological picture of CSF in tubercular meningitis is quite similar to that of viral meningitis showing a mixed population of lymphoid series cells. The presence of epithelioid cell cluster is very rare finding. We present here such a case of 2(1/2) yr old boy who presented with fever off and on for 2 months and altered sensorium along with vomiting for 2-3 days.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/dc.21076 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Disseminated tuberculosis masquerading as a psychiatric illness-A case report.
J Family Med Prim Care
December 2024
Department of Medicine, Universiti Teknologi MARA, Puncak Alam, Malaysia, Asia.
Unlabelled: Tuberculosis (TB) can affect any organ, and at times more than one organ in any sequence, in which case it is referred to as disseminated tuberculosis (DTB). We report a patient who presented primarily for psychiatric symptoms of three months' duration, which later turned out to be a case of DTB involving the central nervous system as well as the spine and lungs.
Case Presentation: An elderly lady with subacute onset and worsening behavioural changes of three months' duration was referred for exclusion of organic brain disease.
Evaluation of the Cerebrospinal Fluid (CSF)-Truenat Assay: A Novel Chip-Based Test in the Diagnosis and Management of Tubercular Meningitis at a Tertiary Care Hospital.
Cureus
November 2024
Emergency Medicine, Sarojini Naidu Medical College, Agra, IND.
Introduction: Tuberculosis (TB) continues to be a major health concern that has a significant impact on morbidity and mortality worldwide. Tubercular meningitis (TBM) may be fatal due to its severe neurological outcomes if not diagnosed and treated promptly. The newer molecular diagnostic techniques have brought significant advancements in the detection of (MTB).
View Article and Find Full Text PDFGlobal burden of tuberculous meningitis in children aged 0-14 years in 2019: a mathematical modelling study.
Lancet Glob Health
January 2025
Sheffield Centre for Health and Related Research, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Background: Tuberculous meningitis is fatal if untreated and can lead to lifelong neurological sequelae. However, to our knowledge, there are no data on the number of children affected by this disease. We aimed to estimate the global disease burden and attributable mortality of childhood tuberculous meningitis by WHO regions, age groups, treatment status, and HIV status in 2019.
View Article and Find Full Text PDFTargeted metabolomics investigation of metabolic markers of Mycobacterium tuberculosis in the cerebrospinal fluid of paediatric patients with tuberculous meningitis.
PLoS One
December 2024
Biochemistry Department, Focus Area for Human Metabolomics, North-West University, Potchefstroom, South Africa.
Article Synopsis
- - This study aimed to explore metabolic markers associated with Mycobacterium tuberculosis (M. tb) in the cerebrospinal fluid (CSF) of South African children suffering from tuberculous meningitis (TBM) using advanced metabolomics techniques.
- - Four key metabolites were found to distinguish TBM patients from controls: lower levels of mannose and arabinose, and higher levels of nonanoic acid and propanoic acid in the TBM group.
- - The research suggests that nonanoic acid may be a novel M. tb-linked marker in TBM, while propanoic acid could indicate brain energy disruptions and inflammation; however, mannose and arabinose were not effective markers for M.
Clinical Significance of Hyponatremia in Tuberculous Meningitis: A Prospective Cohort in Indonesia.
Open Forum Infect Dis
December 2024
Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Indonesia.
Article Synopsis
- Hyponatremia is a common condition among patients with tuberculous meningitis (TBM), occurring in 86.8% of a study cohort; 26% of these cases were classified as severe.
- Severe hyponatremia was associated with younger males, lower Glasgow Coma Scale scores, and increased markers of disease severity, but did not independently predict death in patients with HIV.
- One-year mortality was 46.5%, linked to factors such as age, HIV status, and neurological severity, indicating that treating hyponatremia aggressively might not significantly improve outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!