Neuroleptospirosis with hydrocephalus and very elevated cerebrospinal fluid protein.

South Med J

Department of Neurosurgery, KAT National Hospital, Karaiskaki 23, Neo Psychiko, Attica, Greece.

Published: May 2009

To our knowledge, this is the first known case of a patient with leptospirosis and very elevated CSF, which caused hydrocephalus.

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http://dx.doi.org/10.1097/SMJ.0b013e3181a0ae80DOI Listing

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A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 sequence reads (0.

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To our knowledge, this is the first known case of a patient with leptospirosis and very elevated CSF, which caused hydrocephalus.

View Article and Find Full Text PDF

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