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Background: Navigation surgical systems have been widely used in spinal fusion to ensure accuracy and safety during pedicle screw insertion.
Methods: The research was performed under laboratory conditions, using stereotactic navigation, surgical instruments for spinal fusion, development of additional devices and software. During the experiments, all stages of the computed tomography-guided navigation system use were performed-preoperative preparation of patient data and planning to provide visual control of the navigation of surgical instruments during the insertion of screws.
Application of a 3D Fusion Model to Evaluate the Efficacy of Clear Aligner Therapy in Malocclusion Patients: A Prospective Observational Study.
J Med Internet Res
December 2024
Kunming Medical University Affiliated Stomatological Hospital & Yunnan Key Laboratory of Stomatology, Department of Orthodontics, Kunming Medical University, C Building, Hecheng International1088 Haiyuan Middle Road, Kunming, CN.
Background: Investigating the safe range of orthodontic tooth movement is essential for maintaining oral and maxillofacial stability post-treatment. Although clear aligners rely on pre-treatment digital models, their effect on periodontal hard tissues remains uncertain. By integrating CBCT-derived cervical and root data with crown data from digital intraoral scans, a three-dimensional (3D) fusion model may enhance precision and safety.
View Article and Find Full Text PDFEnDM-CPP: A Multi-view Explainable Framework Based on Deep Learning and Machine Learning for Identifying Cell-Penetrating Peptides with Transformers and Analyzing Sequence Information.
Interdiscip Sci
December 2024
School of Computer Science and Artificial Intelligence, Aliyun School of Big Data, School of Software, Changzhou University, Changzhou, 213164, China.
Cell-Penetrating Peptides (CPPs) are a crucial carrier for drug delivery. Since the process of synthesizing new CPPs in the laboratory is both time- and resource-consuming, computational methods to predict potential CPPs can be used to find CPPs to enhance the development of CPPs in therapy. In this study, EnDM-CPP is proposed, which combines machine learning algorithms (SVM and CatBoost) with convolutional neural networks (CNN and TextCNN).
View Article and Find Full Text PDFAnalysis of the distribution of mechanical load on the plate and lateral hinge of a valgus-producing open wedge high tibial osteotomy during weight-bearing by simulating consolidation. Finite element study.
Orthop Traumatol Surg Res
December 2024
Laboratoire ICube, Université de Strasbourg - CNRS, 4 rue de la Manufacture des Tabacs, 67000 Strasbourg, France; Service de Chirurgie Orthopédique et de Traumatologie, Hôpital de Hautepierre II, 1 Avenue Molière, 67098 Strasbourg Cedex, France. Electronic address:
Introduction: High tibial osteotomy (HTO) is indicated for managing isolated medial knee osteoarthritis in a young patient with a metaphyseal deformity of the proximal tibia. In a medial open-wedge HTO, maintaining the integrity of the hinge is crucial for consolidation and preservation of the correction. Based on a validated model and preliminary results, the objective of this work was to measure and monitor the distribution of mechanical load on a locking fixation plate and the lateral hinge of an HTO using a finite element (FE) model during different phases of consolidation evolution, simulating single leg weightbearing.
View Article and Find Full Text PDFPI-RADS in Predicting csPCa: A Comparison Between Academic and Nonacademic Centers.
Prostate
December 2024
Urology Unit, Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio University', Chieti, Italy.
Introduction: The introduction of multiparametric prostate magnetic resonance imaging (mpMRI) has revolutionized prostate cancer (PCa) diagnosis, enhancing the localization of clinically significant prostate cancer (csPCa) and guiding targeted biopsies. However, significant disparities in the execution, interpretation, and reporting of prostate MRI examinations across centers necessitate greater standardization and accuracy. This study compares the diagnostic efficacy of mpMRI from academic and nonacademic centers in detecting csPCa and identifies factors associated with csPCa detection.
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