Seizure during hyperbaric oxygen therapy for carbon monoxide toxicity: a case series and five-year experience.

Background: Hyperbaric oxygen (HBO) therapy is recommended to reduce the delayed neurologic sequelae resulting from carbon monoxide (CO) toxicity. Although HBO is generally well tolerated, there exists a risk of seizure in all patients that may be increased in patients with predisposing factors including: fever, hypothermia, prior seizure, or brain injury.

Case Report: We present two cases of patients without known risk factors who experienced seizures associated with HBO therapy during treatment for CO toxicity.

Conclusion: This facility's 5-year experience and a review of the germane literature are also presented to elucidate the risk factors and incidence of seizures in patients treated with HBO for CO toxicity.