Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine.

Br J Clin Pharmacol

School of Nursing and Midwifery, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, Western Australia, 6845, Australia.

Published: April 2009

Aims: To investigate the transfer of amphetamines into breast milk following their recreational use and estimate drug exposure for the breastfed infant.

Methods: Two breastfeeding mothers who were occasional recreational users of intravenous amphetamines were studied. A urine sample was collected 4 h after dose, and milk samples were collected over 24 h. Drug in urine was qualitatively identified by gas chromatography-mass spectrometry and quantification in milk was by high-performance liquid chromatography. Absolute infant dose via milk was estimated.

Results: The urines contained predominantly methylamphetamine together with smaller amounts of amphetamine. In the 24 h after dose, average concentrations in milk were 111 microg l(-1) and 281 microg l(-1) for methylamphetamine and 4 microg l(-1) and 15 microg l(-1) for amphetamine in cases 1 and 2, respectively. Absolute infant doses for methylamphetamine plus amphetamine (as methylamphetamine equivalents) were 17.5 microg kg(-1) day(-1) and 44.7 microg kg(-1) day(-1), respectively, for cases 1 and 2.

Conclusion: These limited data suggest that breastfeeding should be withheld for 48 h after recreational amphetamine use.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679109PMC
http://dx.doi.org/10.1111/j.1365-2125.2009.03366.xDOI Listing

Publication Analysis

Top Keywords

microg l-1
16
methylamphetamine amphetamine
8
breast milk
8
milk recreational
8
dose milk
8
absolute infant
8
microg kg-1
8
kg-1 day-1
8
milk
6
microg
6

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!