Various stress factors induce the accumulation of intracellular heat shock proteins, in particular heat shock protein 70 (Hsp70), which is considered as the main component of cellular response to stress. Though initially Hsp70 was thought to be a typical intracellular protein, the strong evidence now exists demonstrating that the Hsp70 exits mammalian cells not only following necrotic cell death but also by a process involving its active release. This review discusses the mechanisms of Hsp70 release and immunomodulatory and signaling functions of extracellular Hsp70.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
heat shock
12
shock protein
8
hsp70
5
[the extracellular
4
extracellular heat
4
protein functions]
4
functions] stress
4
stress factors
4
factors induce
4
induce accumulation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!