Combined pulse-discrete microwave irradiation (9375 and 1765 MHz, irradiance flux density to 375 microW/cm2, by 12 h/day for 4 months) caused faint inhibition of CNS in locomotion activity and defensive reflex parameters.
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Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors.
Signal Transduct Target Ther
November 2024
Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital, School of Medicine, Zhejiang University, 310009, Hangzhou, China.
The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T cells. Here, we developed a bacterial-based adjuvant approach that augments the efficacy of adoptive T-cell therapy for solid tumor treatment. Our study reveals that intratumor injection of E.
View Article and Find Full Text PDFMetabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction.
Circ Heart Fail
November 2024
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.S., R.W.M., R.J.M., S.H.S.).
Article Synopsis
- The study investigates how SGLT2 inhibitors, particularly dapagliflozin, affect metabolism in patients with heart failure (HF) differing by ejection fraction (EF), focusing on ketone and fatty acid changes.
- It analyzed data from two trials involving 527 participants, using metabolomic profiling to identify the effects of dapagliflozin on various metabolites over 12 weeks.
- The findings revealed that dapagliflozin increased certain metabolites associated with ketosis and acylcarnitines but had less effect on amino acids, showing varying impacts depending on the patient's left ventricular ejection fraction.
An operationalization framework for lifecycle health technology assessment: a Health Technology Assessment International Global Policy Forum Task Force report.
Int J Technol Assess Health Care
May 2024
Zorginstituut Nederland (ZIN), Utrecht, Netherlands.
Operationalization guidance is needed to support health technology assessment (HTA) bodies considering implementing lifecycle HTA (LC-HTA) approaches. The 2022 Health Technology Assessment International (HTAi) Global Policy Forum (GPF) established a Task Force to develop a position paper on LC-HTA. In its first paper, the Task Force established a definition and framework for LC-HTA in order to tailor it to specific decision problems.
View Article and Find Full Text PDFLifecycle HTA: promising applications and a framework for implementation. An HTAi Global Policy Forum Task Force report.
Int J Technol Assess Health Care
May 2024
Zorginstituut Nederland (ZIN), Utrecht, Netherlands.
The 2022 Health Technology Assessment International (HTAi) Global Policy Forum (GPF) established the goal of developing a position statement and framework for lifecycle HTA (LC-HTA), through a Task Force leveraging multi-stakeholder monthly discussions and GPF member input. The Task Force developed a working definition: LC-HTA is a systematic process utilizing sequential HTA activities to inform decision making where the evidence base, the health technology itself, or the context in which it is applied, has a potential to meaningfully change at different points in its LC. Four key scenarios were identified where it was considered that an LC-HTA approach would add sufficient value to HTA bodies and their key stakeholders to justify the additional resource burden.
View Article and Find Full Text PDFLyophilized lymph nodes for improved delivery of chimeric antigen receptor T cells.
Nat Mater
June 2024
National Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Lymph nodes are crucial organs of the adaptive immune system, orchestrating T cell priming, activation and tolerance. T cell activity and function are highly regulated by lymph nodes, which have a unique structure harbouring distinct cells that work together to detect and respond to pathogen-derived antigens. Here we show that implanted patient-derived freeze-dried lymph nodes loaded with chimeric antigen receptor T cells improve delivery to solid tumours and inhibit tumour recurrence after surgery.
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