Two new flavanones, (2S)-5-hydroxy-7,4'-di-O-(gamma,gamma-dimethylallyl)flavanone (1) and 6-hydroxy-E-3-(2,5-dimethoxybenzylidine)-2',5'-dimethoxyflavanone (2), together with three known compounds, tephrowatsin C, afrormosin and kaempferol 3-O-beta-D-glucopyranoside were isolated from the roots of Tephrosia calophylla. The structures of 1 and 2 were established by extensive 2D NMR spectral studies.
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Development and characterisation of nine polymorphic microsatellite markers for Tephrosia calophylla Bedd. (Fabaceae).
Saudi J Biol Sci
March 2015
Dept of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia ; College of Science, Andhra University, Waltair, Visakhapatnam, India.
Tephrosia calophylla Bedd. (Fabaceae) is an endangered tropical plant endemic to southwestern Ghats, India. The objective of this study was to contribute to the characterisation of the diversity of this rare species, which is necessary for its future conservation.
View Article and Find Full Text PDFChemical re-examination of the roots of T. calophylla led to the isolation of four isoflavones, namely 2',4',5-trihydroxy-6,7-(2",2"-dimethylchromene)-8-gamma,gamma-dimethylallylisoflavone (1a, auriculatin), 2',5-dihydroxy-6,7-(2",2"-dimethylchromene)-4'-gamma,gamma-dimethylallyloxyisoflavone (2a, isoauriculatin), 3',4',5-trihydroxy-6,7-(2",2"-dimethylchromene)-8-gamma,gamma-dimethylallylisoflavone (1b, auriculasin), and 3',5-dihydroxy-6,7-(2",2"-dimethylchromene)-4'-gamma,gamma-dimethylallyl-oxyisoflavone (2b, isoauriculasin). Auriculasin and isoauriculasin are reported for the first time with full NMR assignments.
View Article and Find Full Text PDFFlavonoids from Tephrosia calophylla.
Nat Prod Commun
January 2009
Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati 517502, India.
Two new flavanones, (2S)-5-hydroxy-7,4'-di-O-(gamma,gamma-dimethylallyl)flavanone (1) and 6-hydroxy-E-3-(2,5-dimethoxybenzylidine)-2',5'-dimethoxyflavanone (2), together with three known compounds, tephrowatsin C, afrormosin and kaempferol 3-O-beta-D-glucopyranoside were isolated from the roots of Tephrosia calophylla. The structures of 1 and 2 were established by extensive 2D NMR spectral studies.
View Article and Find Full Text PDFCytotoxic benzil and coumestan derivatives from Tephrosia calophylla.
Phytochemistry
January 2009
Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical, Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India.
A benzil, calophione A, 1-(6'-Hydroxy-1',3'-benzodioxol-5'-yl)-2-(6''-hydroxy-2''-isopropenyl-2'',3''-dihydro-benzofuran-5''-yl)-ethane-1,2-dione and three coumestan derivatives, tephcalostan B, C and D were isolated from the roots of Tephrosia calophylla. Their structures were deduced from spectroscopic data, including 2D NMR (1)H-(1)H COSY and (13)C-(1)H COSY experiments. Compounds were evaluated for cytotoxicity against RAW (mouse macrophage cells) and HT-29 (colon cancer cells) cancer cell lines and antiprotozoal activity against various parasitic protozoa.
View Article and Find Full Text PDFBetulinic acid binding to human serum albumin: a study of protein conformation and binding affinity.
J Photochem Photobiol B
January 2009
Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India.
Betulinic acid (BA) has anti cancer and anti-HIV activity and has been proved to be therapeutically effective against cancerous and HIV-infected cells. Human serum albumin (HSA) is the predominant protein in the blood. Most drugs that bind to HSA will be transported to other parts of the body.
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