Evidence-informed decision-making supports high-quality, efficient healthcare. Programs such as SEARCH Classic (Swift Efficient Application of Research in Community Health) and EXTRA (Executive Training for Research Application) give health system decision-makers the skills and experience required to apply the best evidence to their work. But effectively leading change in how evidence comes to bear on the overall management and delivery of care requires strategies aimed at whole organizations and systems. The Canadian Health Services Research Foundation (CHSRF, EXTRA's managing organization) and SEARCH Canada (the SEARCH Classic program's managing organization) recently launched a jointly commissioned research study to assess organizational mechanisms and the impacts of these programs. Moving away from a focus on individual trainees and their immediate organizational connections, this evaluation builds on the evidence to date that leads to the hypothesis that a critical mass of highly educated, evidence-savvy decision-makers (senior executives in the case of EXTRA; middle- and front-line managers in the case of SEARCH Canada) enhance organizational capacity to use knowledge and ultimately lead to a more systematic use of evidence at the systems level (Champagne et al. 2008).
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http://dx.doi.org/10.12927/hcq.2009.20673 | DOI Listing |
Toxics
December 2024
The Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Amines are widespread environmental pollutants that may pose health risks. Specifically, the N-dealkylation of amines mediated by cytochrome P450 enzymes (P450) could influence their metabolic transformation safety. However, conventional experimental and computational chemistry methods make it difficult to conduct high-throughput screening of N-dealkylation of emerging amine contaminants.
View Article and Find Full Text PDFPathogens
December 2024
Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
: Urinary tract infections (UTIs) are among the most prevalent bacterial infections. With many patients turning to the Internet as a health resource, this study seeks to understand public engagement with online resources concerning recurrent UTIs (rUTIs), assess their reliability, and identify common questions/concerns about rUTIs. : Social media analysis tool BuzzSumo was used to calculate online engagement (likes, shares, comments, views) with information on rUTIs.
View Article and Find Full Text PDFPathogens
December 2024
Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
is a body-louse-borne bacterium. Canadian disease has been reported primarily in populations experiencing homelessness and in Indigenous communities with limited access to water. We sought to understand the epidemiology of in Canada.
View Article and Find Full Text PDFInsects
December 2024
Laboratorio de Biotecnología I, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario S/N Nuevo Campus Universitario, Chihuahua 31125, Chihuahua, Mexico.
In the search for effective strategies to control the Colorado Potato Beetle, RNA interference technology has emerged as a promising method due to its capacity to suppress genes selectively. Factors such as the target gene and double-stranded RNA (dsRNA) length are critical for optimizing gene silencing efficiency. In this study, we designed and synthesized in vitro dsRNAs of varying lengths targeting the gene, which encodes the AChE1 isoform of acetylcholinesterase in the beetle.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Molecular Biology, Ariel University, Ariel 40700, Israel.
Loss of function screens using shRNA (short hairpin RNA) and CRISPR (clustered regularly interspaced short palindromic repeats) are routinely used to identify genes that modulate responses of tumor cells to anti-cancer drugs. Here, by integrating GSEA (Gene Set Enrichment Analysis) and CMAP (Connectivity Map) analyses of multiple published shRNA screens, we identified a core set of pathways that affect responses to multiple drugs with diverse mechanisms of action. This suggests that these pathways represent "weak points" or "Achilles heels", whose mild disturbance should make cancer cells vulnerable to a variety of treatments.
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