Summary: The program Fluctuation AnaLysis CalculatOR (FALCOR) is a web tool designed for use with Luria-Delbrück fluctuation analysis to calculate the frequency and rate from various mutation assays in bacteria and yeast. Three calculation methods are available through this program: (i) Ma-Sandri-Sarkar Maximum Likelihood Estimator (MSS-MLE) method, (ii) Lea-Coulson method of the median (LC) and (iii) frequency.
Availability: The FALCOR rate calculator is currently accessible at http://www.mitochondria.org/protocols/FALCOR.html. This program is written as a Java Applet, requiring a web browser enabled with Sun MicroSystems' Java Virtual Machine.
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http://dx.doi.org/10.1093/bioinformatics/btp253 | DOI Listing |
BMC Biol
December 2024
State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Background: Global climate change significantly impacts ecosystems, particularly through temperature fluctuations that affect insect physiology and behavior. As poikilotherms, insect pests such as the globally devastating diamondback moth (DBM), Plutella xylostella, are especially vulnerable to rising temperatures and extreme heat events, necessitating effective adaptive mechanisms.
Results: Here we demonstrate the roles of zinc finger proteins (ZFPs) in mediating thermal adaptability in DBM.
J Epidemiol Community Health
December 2024
Population Research Centre, Faculty of Spatial Sciences, University of Groningen, Groningen, The Netherlands.
Background: Seasonal fluctuations in mortality affect annual life expectancy at birth (e). Nevertheless, evidence on the impact of seasonal mortality on longevity is very limited and mainly restricted to assessing season-specific mortality levels due to shocks (e.g.
View Article and Find Full Text PDFJMIR Form Res
December 2024
Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, Netherlands, 31 053 489 9111.
Background: With the growing need of support for informal caregivers (ICs) and care recipients (CRs) during COVID-19, the uptake of digital care collaboration platforms such as Caren increased. Caren is a platform designed to (1) improve communication and coordination between ICs and health care professionals, (2) provide a better overview of the care process, and (3) enhance safe information sharing within the care network. Insights on the impact of COVID-19 on the implementation and use of informal care platforms such as Caren are still lacking.
View Article and Find Full Text PDFPLoS One
December 2024
School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, Shenzhen, Guangdong, China.
In the process of pushing the limits of human performance, competitive sports are dedicated to the pursuit of excellence. In this context, the concept of "momentum" has gained significant attention, as it is widely acknowledged to influence the outcomes of competitions. The question of whether momentum affects sports psychology and the mechanisms underlying its generation and influence merits thorough investigation.
View Article and Find Full Text PDFLangmuir
December 2024
Department of Biomedical and Chemical Engineering and the Bioinspired Institute, Syracuse University, Syracuse, New York 13244, United States.
Copolymer nanovesicles are used extensively in chemical processes and biomedical applications in which they are subjected to dynamic flow environments. Flow-induced vesicle deformation, fragmentation, and reorganization modify the energetic (e.g.
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