The blood plasma erythropoietin content, erythropoietin content, erythropoietin and cellular renovation markers expression in exocervical epithelium in reproductive aged women with normal peripheral red blood values were studied. It was determined that erythropoietin expression increased in exocervical epithelium activity (cervical intraepithelial neoplasia 1 and 2), combined with the increase of blood plasma erythropoietin level, activation of pro- and antiapoptosis programs and cellular proliferation processes in cervical epithelium.
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Endometrial cancer in transgender men is rare, and its histopathologic features remain unknown. A 30-yr-old transgender man with an intrauterine tumor, an ovarian mass, and a 2-yr history of testosterone use was referred to us for treatment. The presence of the tumors was confirmed via imaging, and the intrauterine tumor was identified as an endometrial endometrioid carcinoma via endometrial biopsy.
View Article and Find Full Text PDFEcancermedicalscience
December 2018
Faculty of Medicine, Central University of Venezuela, Caracas 1050, Venezuela.
Human papillomavirus (HPV) is the causative agent of cervical cancer (CC), the second most common cause of cancer deaths in Venezuela. Early detection and prompt treatment of precancerous lesions prevent up to 80% of CC cases. In Venezuela, difficult access to CC screening means that the disease is detected at advanced stages, especially in more vulnerable indigenous populations.
View Article and Find Full Text PDFRom J Morphol Embryol
September 2015
Dermatology Clinic, Mures County Hospital; Department of Dermatology, University of Medicine and Pharmacy of Tirgu Mures, Romania;
Squamous cell carcinoma is defined as an invasive epithelial neoplasm, with variable degrees of squamous differentiation, with or without keratinization. It is origins stand at the level of the keratinized stratified squamous epithelium (skin) or non-keratinized (oral mucosa, esophageal mucosa, uterine exocervical mucosa), but it can also be found in squamous metaplasia areas (uterine endocervix or trachea-bronchial tree). This report presents the case of an oral squamous cell carcinoma as a second malignancy in the same anatomical territory, in a patient with prior treatment for chondrosarcoma, both surgical and radiotherapy.
View Article and Find Full Text PDFOpt Express
June 2013
Laboratoire de Physique des Interfaces et des Couches Minces (LPICM), Ecole polytechnique, CNRS, 91128 Palaiseau, France.
We present a preliminary investigation of macroscopic polarimetric imaging of uterine cervix. Orthogonal state contrast (OSC) images of healthy and anomalous cervices have been taken in vivo at 550 nm. Four ex vivo cervix samples have been studied in full Muller polarimetry, at 550 nm and 700 nm, and characterized in detail by standard pathology.
View Article and Find Full Text PDFArch Gynecol Obstet
August 2013
Department of Gynecology, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China.
Purpose: To understand the pathogenesis of cervical cancer (CC) associated with polarity protein αPKC and the potential roles of αPKC in clinical management of CC.
Methods: Tissue samples were collected from women who received colposcopy biopsy or hysterectomy surgery, including 9 CIN1, 8 CIN2, 15 CIN3, and 12 invasive cervical squamous cancer (ICC). 16 normal controls were from the normal region of tumor samples, HE and immunofluorescence staining of αPKC were performed on these samples.
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