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Association study of the HLA class I system with psoriatic arthritis in Southern Tunisia: a case-control study.
Clin Rheumatol
December 2024
Immunology and Histocompatibility Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Introduction/objectives: Psoriatic arthritis (PsA) is a chronic inflammatory rheumatism belonging to the spondyloarthritis family. It is a multifactorial disease whose genetic determinism is still poorly understood. It is favored by environmental factors in genetically predisposed individuals.
View Article and Find Full Text PDFThe HLA-B*27:264 Allele Identified in a Volunteer Donor for Haematopoietic Stem Cell Transplant.
HLA
November 2024
Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
HLA-B*27:264 differs from HLA-B*27:05:02:01 in codon 49 in exon 2.
View Article and Find Full Text PDFAcute anterior uveitis (AAU) is a common extra-articular manifestation of ankylosing spondylitis (AS), particularly in patients positive for the human leucocyte antigen (HLA)-B27 genetic marker. To explore the underlying mechanisms of HLA-B27 AS-associated AAU, we employed single-cell RNA sequencing to profile the transcriptomes of peripheral blood mononuclear cells in three HLA-B27 AS-associated AAU patients and three healthy controls (HCs). We identified 11 distinct immune cell clusters, with a particular focus on monocytes, revealing six subsets, including three previously unidentified subsets, namely, GTPase immune-associated proteins, Th17-related, and lncRNA monocytes, with unique gene expression patterns.
View Article and Find Full Text PDFAnalysis of , and Polymorphisms in Patients with Ankylosing Spondylitis in a Chinese Han Population: A Case-Control Study.
Genet Test Mol Biomarkers
October 2024
Department of Orthopaedics, Tianjin Hospital, Tianjin, China.
Earlier research has demonstrated a genetic basis for the susceptibility to ankylosing spondylitis (AS) and the severity of AS. By employing a genome-wide association study, recent work has established a correlation between the susceptibility to AS and the and genes in a Western study population-though alternative studies have not corroborated these findings. This study aims to examine the effects of , , and polymorphisms on the susceptibility and severity of AS among the predominantly Chinese Han population.
View Article and Find Full Text PDFArtificial intelligence improves the diagnosis of human leukocyte antigen (HLA)-B27-negative axial spondyloarthritis based on multi-sequence magnetic resonance imaging and clinical features.
Quant Imaging Med Surg
August 2024
Department of Radiology, The Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics, Guangdong Province), Guangzhou, China.
Article Synopsis
- Axial spondyloarthritis (axSpA) is often diagnosed late in HLA-B27-negative patients, leading to missed treatment opportunities, prompting the development of an AI tool called NegSpA-AI to improve diagnosis using MRI and clinical features.
- The study analyzed data from 454 HLA-B27-negative patients, using various MRI techniques and applying deep learning for axSpA versus non-axSpA differentiation, split across training and testing groups.
- NegSpA-AI outperformed junior rheumatologists in diagnostic accuracy, demonstrated by high areas under the curve in multiple test sets, and significantly improved the performance of radiologists when used as an assistive tool.
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