A New fluorescent sensor based on a perylene-dpa-Zn platform was synthesized. Selective "Off-On" type fluorescence changes were observed upon the addition of UTP and UDP, which was also applied to monitor glycosylation processes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol9004849 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of Off-On Near-Infrared Fluorescent Probes for Sensitive In Vivo Imaging of Amyloid-β Species with Enhanced Pharmacokinetic.
Chemistry
January 2025
Shanghai Institute of Materia Medica Chinese Academy of Sciences, State Key Laboratory of Drug Research, CHINA.
The fluorescent imaging of pathologically accumulated β-amyloid (Aβ) proteins is of significant importance to the diagnosis of Alzheimer's disease (AD). In the paper, we prepared two new NIR probes, NIR-1 and NIR-2, through hydrophilic modification of introducing water-soluble bioactive groups such as polyethylene glycol (PEG) and morpholine to tune in vivo pharmacokinetics for specific detection of soluble and insoluble Aβ species. The in vitro assessments confirm that both NIR-1 and NIR-2 display strong near-infrared (NIR) fluorescence (FL) enhancement upon association with Aβ42 monomers, oligomers or aggregates (λem > 670 nm) and show high sensitive, rapid and selective response towards Aβ42 species.
View Article and Find Full Text PDFSwitch-Type Electrochemiluminescence Aptasensor for AFB1 Detection Based on CoS Quantum Dots Encapsulated in Co-LDH and a Ferrocene Quencher.
Anal Chem
January 2025
Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
Among the various aflatoxin B1 (AFB1) assays, performing accurate detection is difficult because false positives and false negatives are frequent due to limited sensitivity, expensive equipment, or inadequate pretreatment during operation. Here, an "off-on" switch-type electrochemiluminescence (ECL) aptasensor armed with cobalt-sulfur quantum dots was encapsulated in hollow cobalt-layered double hydroxide nanocages as an enhanced luminescent probe (Co-LDH@QDs), and a ferrocene-modified aptamer (Fc-APT) was used as a luminescent quencher. In general, when Fc-APT was hybridized with complementary DNA modified with a DNA nanotetrahedron, electron transfer between ferrocene and Co-LDH@QDs was facilitated, leading to efficient quenching of the ECL intensity into an "off" state in the absence of AFB1.
View Article and Find Full Text PDFColorimetric and fluorescence dual-signal sensing of L-Arginine based on TSPP-TA.
Spectrochim Acta A Mol Biomol Spectrosc
November 2024
The 4th People's Hospital of Qinghai Province, Xining 810007, China. Electronic address:
Article Synopsis
- L-Arginine (L-Arg) is a crucial amino acid for human growth, and imbalances in its levels can lead to health issues, making its quantification important in life sciences.
- A new sensing system was developed using 5,10,15,20-(4-sulphonatophenyl)porphyrin (TSPP) that demonstrates colorimetric and fluorescence changes when L-Arg is present, toggling between "ON" and "OFF" states with specific color transitions.
- The system can accurately detect L-Arg concentrations, showing a linear detection range of 3.14 to 145.20 μM in colorimetric sensing and 1.49 to 271.74
Tetraarylpyrrolo[3,2-]pyrrole-BODIPY dyad: a molecular rotor for FRET-based viscosity sensing.
Front Chem
October 2024
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India.
With the aim to develop a FRET-based viscosity sensor, two dyad molecules, and , comprising tetraarylpyrrolo[3,2-]pyrrole (TAPP) (donor) and naked boron-dipyrromethene (BODIPY) dyes (acceptor), were designed. Dyads were synthesized via acid-catalyzed multicomponent reactions followed by Sonogashira coupling. In both dyads, the BODIPY and TAPP moieties are linked through phenylethynyl groups, which allow free rotation of the BODIPY dyes; that is, they can act as molecular rotors.
View Article and Find Full Text PDFPain Fluctuations in Parkinson's Disease and Their Association with Motor and Non-Motor Fluctuations.
J Parkinsons Dis
October 2024
Department of Neurology, University of Rostock, Rostock, Germany.
Background: Pain fluctuations are a characteristic phenomenon in advanced Parkinson's disease (PD), but their temporal association with motor and non-motor symptom (NMS) fluctuations remains largely enigmatic. Moreover, data on their importance for disease severity perception and health-related quality-of-life (hr-QoL) is limited.
Objective: To dissect pain fluctuations with respect to pain type and frequency patterns, and their association with motor and non-motor fluctuations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!