Objective: The purpose of this study was to assess the value of intraoperative frozen section diagnosis in thyroid surgery and determine its limitations.
Methods: This retrospective study examined the results of 409 frozen sections of thyroid specimens analyzed over the 4-year period and their correlations with the final histological examination.
Results: In our series, frozen section diagnosis was concordant with subsequent histopathological examination in 96.6% of cases, discordant in 3.4%. All discordances were due to false-negative diagnoses. Non-false-positive result was found. The global specificity of frozen section analysis for all histological subtypes was 100% and its sensitivity was 68.2%.
Conclusion: The frozen section evaluation of thyroid neoplasm is highly accurate and specific. A high degree of specificity with an acceptable sensitivity is requested. However, the frozen section examination has still some limits in the diagnosis of microfollicular lesions.
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| http://dx.doi.org/10.1016/j.annpat.2009.01.002 | DOI Listing |
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