[Colchicine intoxication in four elderly patients: how to prevent it?].

Rev Med Interne

Centre régional de pharmacovigilance, CHU Côte-de-Nacre, avenue de la Côte-de-Nacre, BP 95182, 14033 Caen cedex 9, France.

Published: September 2009

Introduction: In France, unlike other countries, the use of colchicine is preferred to other anti-inflammatory drugs for the treatment of gout.

Case Reports: We report a case series of four elderly patients (range from 72 to 83 years of age) who presented with colchicine intoxication, all notified to the Basse-Normandie pharmacovigilance centre in 2007. For each patient, one or more risk factors were identified: renal failure, high initial dosage, absence of laboratory monitoring.

Conclusion: It would be useful to establish specific guidelines for colchicine use in the elderly population.

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http://dx.doi.org/10.1016/j.revmed.2009.03.013DOI Listing

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