In their earlier methodological model studies the authors confirmed the protective effect of atropine in inhalative acetylcholine provocation. In the present work the role of parasympatholysis is investigated in histamine-induced bronchospasm by the method. It was found that a protective effect was exerted in histamine provocation repeated 20 minutes after subcutaneous administration of atropine sulphate in a dose of 0.01 mg/kg. The protective effect proved independent of the individual histamine sensitivities of the patients. The initial value of the CO2 curve prior to provocation was not improved.
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