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Role of mouse adenovirus type 1 E4orf6-induced degradation of protein kinase R in pathogenesis.
J Virol
December 2024
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Protein kinase R (PKR) is an interferon-induced antiviral protein activated by autophosphorylation in response to double strand DNA (dsRNA) and other stimuli. Activated PKR causes translation inhibition and apoptosis, and it contributes to proinflammatory responses, cell growth, and differentiation. Mouse adenovirus type 1 (MAV-1) counteracts PKR by causing its degradation via a viral protein, early region 4 open reading frame 6 (E4orf6).
View Article and Find Full Text PDFSome Comply While Some Defy: Elementary Teachers' Responses to Leadership Mandates on Reading Comprehension Instruction.
Lang Speech Hear Serv Sch
December 2024
School of Education, Edith Cowan University, Perth, Western Australia, Australia.
Purpose: We report the qualitative findings from a survey of elementary teachers regarding reading instruction. The purpose is to extend on quantitative findings in a previously described survey to gain a more in-depth understanding of Australian elementary teachers' approaches to the literacy block in their schools: how this is used, who makes instructional decisions, and how teachers respond to these.
Method: A web-based survey was used to collect data from Australian elementary teachers about their perspectives regarding reading comprehension instruction.
Navigating a fine balance: point-mutant cheater viruses disrupt the viral replication cycle.
Mol Biol Evol
December 2024
The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv, Israel.
Cheater viruses cannot replicate on their own yet replicate faster than the wild type (WT) when the two viruses coinfect the same cell. Cheaters must possess dual genetic features: a defect, which leads to their inability to infect cells on their own, and a selective advantage over WT during co-infection. Previously, we have discovered two point-mutant cheaters of the MS2 bacteriophage.
View Article and Find Full Text PDFAn annotated introductory reading list for neurodiversity.
Elife
December 2024
Ask Me, I'm an AAC user, United States, United States.
Article Synopsis
- The concept of neurodiversity is complex and has many definitions, which can confuse those wanting to learn about it.
- A collaborative reading list created by neurodiverse researchers addresses the lack of curated information by covering nine key themes related to neurodiversity.
- The resource aims to enhance understanding of neurodiversity and guide researchers toward more inclusive and rigorous scientific practices.
Article Synopsis
- Critical reviews of test measurement validity can be misleading if they mix discussions of poor test usage with validity evidence, leading readers to incorrect conclusions.
- Test reviewers should focus equally on a test's external validity, as overemphasis on internal metrics like factor analysis can skew perceptions of the test's overall effectiveness.
- The authors critique Higgins et al.'s (2024) review of the Reading the Mind in the Eyes Test, arguing that it unfairly recommended abandoning the test based on a flawed evaluation of its psychometric and external validity.
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