To assess the feasibility and relevance of using lymphoblastoid cell lines to study the role of noncoding RNAs in the etiology of autism, we evaluated global expression profiling of 470 mature human microRNAs from six subjects with autism compared with six matched controls. Differential expression (either higher or lower) for 9 of the 470 microRNAs was observed in our autism samples compared with controls. Potential target genes for these microRNAs were identified using computer tools, which included several autism susceptibility genes. Our preliminary results indicate microRNAs should be considered and evaluated in the etiology of autism. In addition, analysis of this class of noncoding RNAs in lymphoblastoid cells has the potential to reveal at least a subset of brain-related microRNAs implicated in autism. Subsequently, this model system should allow for detection of complex subtle changes in susceptibility genes/pathways contributing to autism.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768334 | PMC |
| http://dx.doi.org/10.1002/aur.33 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feasibility and effects of cognitive training on cognition and psychosocial function in Huntington's disease: a randomised pilot trial.
J Neurol
January 2025
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, Victoria, 3800, Australia.
Background: Huntington's disease (HD) is a rare neurodegenerative disease that causes progressive cognitive, physical, and psychiatric symptoms. Computerised cognitive training (CCT) is a novel intervention that aims to improve and maintain cognitive functions through repeated practice. The effects of CCT have yet to be established in HD.
View Article and Find Full Text PDFStructured hernia surgery training program for general practitioners in Rwanda - feasibility and evaluation.
Hernia
January 2025
Department of General and Abdominal Surgery, Clinic for General and Abdominal Surgery, University Hospital Brandenburg an der Havel, Hochstrasse 29, 14770, Brandenburg an der Havel, Germany.
Background: Hernias are among the most common surgical conditions worldwide, with significant prevalence in Africa. However, according to recent WHO statistics, Africa faces a critical shortage of trained surgeons. Structured surgical training programs are also scarce.
View Article and Find Full Text PDFResults of ICE-Guided Isolation of the Superior Vena Cava With Pulsed Field Ablation.
JACC Clin Electrophysiol
January 2025
Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA; Interventional Electrophysiology, Scripps Clinic, San Diego, California, USA; Metro Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; Department of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy. Electronic address:
Background: Earlier studies have documented the risk for sinoatrial node injury and phrenic nerve paralysis as complications following radiofrequency catheter ablation for electrical isolation of the superior vena cava (SVCI).
Objectives: The aim of this study was to assess the safety and feasibility of SVCI in patients with atrial fibrillation undergoing pulsed field ablation (PFA) METHODS: Six hundred sixteen consecutive patients undergoing PFA for pulmonary vein isolation plus SVCI were included in this multicenter analysis. Superior vena cava (SVC) ablation was performed under the continuous guidance of intracardiac echocardiography.
Content Validity of a New Soccer (Football) Return-to-Play Test: The RONDO-TEST.
J Funct Morphol Kinesiol
December 2024
Institut Nacional d'Educació Física de Catalunya (INEFC), Partida la Caparrella, 97, E-25192 Lleida, Spain.
Objectives: The aim was to assess the content validity of a new field test on general and soccer-specific motor skills before return to play.
Methods: The RONDO-TEST was assessed by a Delphi panel for its content validity. It included a survey to evaluate 16 items related to the test consisting of four 10 m lines which cross over at their mid-point, resulting in eight 5 m sectors that include locomotor skills (speeding, moving sideways, side cutting, and jumping) and soccer-specific technical skills (dribbling, slalom course, and kicking/passing).
A Mixed Methods Approach to Korean-Youth Mental Health First Aid (K-YMHFA): A Pilot Study.
J Evid Based Soc Work (2019)
January 2025
Department of Psychology, University of Alabama, Tuscaloosa, USA.
Purpose: Korean immigrant families are growing in the Southern United States (U.S), an area where culturally specific resources can be limited. Korean immigrant families encounter distress in navigating the American culture, but cultural stigma impedes discussion within the family.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!