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Unusual Causes of Death Due to Constipation.
Am J Forensic Med Pathol
December 2024
Forensic Pathology Unit, Royal Darwin Hospital, Darwin, Northern Territory and College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Constipation is found in individuals with intellectual disabilities, autism, and cerebral palsy. Although generally a benign condition, it may lead to life-threatening intestinal obstruction, with or without volvulus, or to stercoral ulceration with enteritis and/or perforation. Two unusual cases of lethal chronic constipation are reported to demonstrate other very rare fatal mechanisms that may occur.
View Article and Find Full Text PDFValentino's Syndrome in the Era of Advanced Imaging and Minimally Invasive Surgery.
Cureus
November 2024
General Surgery, Unidade Local de Saúde de São José, Lisbon, PRT.
Valentino's syndrome is a rare but potentially lethal differential diagnosis for acute appendicitis. We herein present the case of a 22-year-old male patient who presented to the emergency department with acute abdominal pain. Clinical suspicion of acute appendicitis was corroborated by analytical and imaging findings.
View Article and Find Full Text PDFA Phase 1b study of the OxPhos inhibitor ME-344 with bevacizumab in refractory metastatic colorectal cancer.
Invest New Drugs
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Division of Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Antiangiogenic drugs may cause vascular normalization and correct hypoxia in tumors, shifting cells to mitochondrial respiration as the primary source of energy. In turn, the addition of an inhibitor of mitochondrial respiration to antiangiogenic therapy holds potential to induce synthetic lethality. This study evaluated the mitochondrial inhibitor ME-344 in combination with bevacizumab in patients with refractory metastatic colorectal cancer (mCRC).
View Article and Find Full Text PDFTrends, age shifts, and potential delayed peaks post-pandemic of early-onset brain and central nervous system cancers in individuals aged 20-49: a cross-sectional study.
Int J Surg
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Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Background: Central nervous system (CNS) cancers are highly lethal and increasingly affect younger populations aged 20-49, posing significant challenges to global healthcare systems. Current research on early-onset CNS cancer trends is limited and outdated, with uncertain impacts from the COVID-19 pandemic. This study explores the epidemiology of early-onset CNS cancer and the pandemic's effects.
View Article and Find Full Text PDFCavo-Atrial Inferior Vena Cava (IVC) Restoration With Polytetrafluoroethylene Graft: Overcoming Lethal Injuries.
Cureus
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Hepato-Pancreato-Biliary Surgery and Liver Transplantation, London Bridge Hospital, London, GBR.
Injuries to the inferior vena cava (IVC) carry high risks and mortality rates. We present a case of suprahepatic IVC injury that was successfully treated with polytetrafluoroethylene (PTFE) graft insertion without cardiopulmonary bypass. A 46-year-old woman was transferred to our trauma centre after a high-speed motor vehicle collision.
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