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Advances in liver organoids: replicating hepatic complexity for toxicity assessment and disease modeling.
Stem Cell Res Ther
January 2025
Organoid Innovation Center, Suzhou Institute of Nanotech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Rd, Suzhou, Jiangsu, 215123, China.
The lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applications. Traditional cellular and animal models, while widely used, have significant limitations in replicating the liver's complex responses to various stressors. Liver organoids derived from human pluripotent stem cells, adult stem cells primary cells, or tissues can mimic diverse liver cell types, major physiological functions, and architectural features.
View Article and Find Full Text PDFAntioxidant and hepatic fibrosis-alleviating effects of selenium-modified Bletilla striata polysaccharide.
Int J Biol Macromol
January 2025
National Engineering Laboratory for Resource Development of Endangered Crude, Drugs in Northwest China, Shaanxi Normal University, Xi'an 710119, China; Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education, Xi'an 710119, China; College of Life Sciences, Shaanxi Normal University, Xi'an 710119, China. Electronic address:
Liver fibrosis is a significant precursor to cirrhosis and liver cancer, yet effective treatments remain elusive. Our previous studies demonstrated that Bletilla striata polysaccharide (BSP) has therapeutic effects, though it performed poorly at medium concentrations. To address this limitation, BSP underwent selenization modification.
View Article and Find Full Text PDFp16 promoted progress of MCT induced pulmonary hypertension via maintaining redox balance and autophagy pathway.
Biochem Biophys Res Commun
January 2025
Department of Cardiology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214062, China. Electronic address:
Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance and elevated pulmonary arterial pressure. Currently, pathogenesis of PAH remains poorly understood, and therapeutic options are limited. In this study, we aimed to explore role of p16INK4A (p16) in the development of PAH using mouse model induced by monocrotaline (MCT).
View Article and Find Full Text PDFAberrant promoter methylation of CTHRC1 gene and its clinicopathological characteristics in head and neck cancer.
Int J Oral Maxillofac Surg
January 2025
Molecular Biology Laboratory, Centre for Cellular and Molecular Research, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India. Electronic address:
Head and neck squamous cell carcinoma (HNSCC) is genetically complex and difficult to treat. Detection in the early stage is challenging, leading to diagnosis at advanced stages with limited treatment options. This study examined the collagen triple helix repeat containing 1 gene (CTHRC1) as a potential biomarker and therapeutic target in HNSCC.
View Article and Find Full Text PDFRecombinant Antibodies Inhibit Enzymatic Activity of the E3 Ubiquitin Ligase CHIP via Multiple Mechanisms.
J Biol Chem
January 2025
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:
Carboxyl-terminus of Hsp70-Interacting Protein (CHIP) is an E3 ubiquitin ligase that marks misfolded substrates for degradation. Hyper-activation of CHIP has been implicated in multiple diseases, including cystic fibrosis and cancer, suggesting that it may be a potential drug target. However, there are few tools available for exploring this possibility.
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