This work presents methodology based on nuclear technique and artificial neural network for volume fraction predictions in annular, stratified and homogeneous oil-water-gas regimes. Using principles of gamma-ray absorption and scattering together with an appropriate geometry, comprised of three detectors and a dual-energy gamma-ray source, it was possible to obtain data, which could be adequately correlated to the volume fractions of each phase by means of neural network. The MCNP-X code was used in order to provide the training data for the network.
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http://dx.doi.org/10.1016/j.apradiso.2009.02.093 | DOI Listing |
JAMA Cardiol
January 2025
National Heart and Lung Institute, Imperial College London, United Kingdom.
Importance: Hypertension underpins significant global morbidity and mortality. Early lifestyle intervention and treatment are effective in reducing adverse outcomes. Artificial intelligence-enhanced electrocardiography (AI-ECG) has been shown to identify a broad spectrum of subclinical disease and may be useful for predicting incident hypertension.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Institute for Applied Mathematics, University of Bonn, Bonn, Germany.
Purpose: To quantify outer retina structural changes and define novel biomarkers of inherited retinal degeneration associated with biallelic mutations in RPE65 (RPE65-IRD) in patients before and after subretinal gene augmentation therapy with voretigene neparvovec (Luxturna).
Methods: Application of advanced deep learning for automated retinal layer segmentation, specifically tailored for RPE65-IRD. Quantification of five novel biomarkers for the ellipsoid zone (EZ): thickness, granularity, reflectivity, and intensity.
J Am Chem Soc
January 2025
Molecular Sensing and Imaging Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Nanopore technology holds great potential for single-molecule identification. However, extracting meaningful features from ionic current signals and understanding the molecular mechanisms underlying the specific features remain unresolved. In this study, we uncovered a distinctive ionic current pattern in a K238Q aerolysin nanopore, characterized by transient spikes superimposed on two stable transition states.
View Article and Find Full Text PDFJ Med Chem
January 2025
State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Target identification is a critical stage in the drug discovery pipeline. Various computational methodologies have been dedicated to enhancing the classification performance of compound-target interactions, yet significant room remains for improving the recommendation performance. To address this challenge, we developed TarIKGC, a tool for target prioritization that leverages semantics enhanced knowledge graph (KG) completion.
View Article and Find Full Text PDFSoft Matter
January 2025
Department of Mechanical and Aerospace Engineering, University at Buffalo, Buffalo, NY 14260, USA.
Monolayer assembly of charged colloidal particles at liquid interfaces opens a new avenue for advancing the additive manufacturing of thin film materials and devices with tailored properties. In this study, we investigated the dynamics of electrosprayed colloidal particles at curved droplet interfaces through a combination of physics-based computational simulations and machine learning. We employed a novel mesh-constrained Brownian dynamics (BD) algorithm coupled with Ansys® electric field simulations to model the transport and assembly of charged particles on a non-spherical droplet surface.
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