Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/187231207779814337 | DOI Listing |
Publication Analysis
Top Keywords
rat cyp1a1
8
cyp1a1 cyp1a2
8
vitro inhibition
4
inhibition rat
4
cyp1a2 piceatannol
4
piceatannol hydroxylated
4
hydroxylated metabolite
4
metabolite trans-resveratrol
4
trans-resveratrol piceatannol
4
piceatannol parent
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!