In the town of Dimitrovgrad, the total ambient pollution was 14.0-16.2 and 1.5-1.8 in the west (polluted) and central (pure) districts, respectively. The major pollutants were nitric dioxide, sulfur dioxide, carbon dioxide, phenol, and formaldehyde. In the women living in the west district, the major reproductive functional abnormalities were bacterial vaginosis, neurometabolic-endocrine syndrome, and chronic small pelvic inflammatory diseases. The findings are indicative of a significant impairment in the physiological relationship between the values of hormones and immunity in patients with the neurometabolic-endocrine syndrome from the polluted district versus those with the same syndrome from the pure district and versus healthy women.

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