Background: Morbid obesity can reduce the health-related quality of life (HRQL) and paid work participation, and the duodenal switch (DS) can induce large weight loss in patients suffering from this disease. However, data about HRQL combined with paid work participation after duodenal switch are lacking. The aim of this study was to provide longitudinal data of these issues.
Methods: Fifty-one consecutive morbidly obese patients accepted for DS gave their informed consent to participate in the study. Mean age was 37.7 years (SD, 8.0), and 54.9% were women. HRQL was assessed using the "Short-Form 36 Health Status Survey". Eight subscores, the physical component summary (PCS), and the mental component summary (MCS) were calculated. Paid-work participation was assessed as performing or not performing paid work. Data were assessed before DS (T0), 1 year after DS (T1), and 2 years after DS (T2).
Results: All the SF-36 scores improved significantly from T0 to T1 and T2 (p < 0.001), when they were in the normal range compared to the population norm. The number of patients performing paid work increased from 28 (54.9%) at T0 to 34 (66.7%) at T2, p = 0.031. The patients who performed paid work had significantly better PCS and MCS scores than those who did not before, but not after, DS.
Conclusion: Our data indicate that the SF-36 scores of the patients were normalized after DS. A marked improvement in the paid work participation was also observed.
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http://dx.doi.org/10.1007/s11695-009-9837-3 | DOI Listing |
Introduction: Age-associated depletion in nicotinamide adenine dinucleotide (NAD+) concentrations has been implicated in metabolic, cardiovascular, and neurodegenerative disorders. Supplementation with NAD+ precursors, such as nicotinamide riboside (NR), offers a potential therapeutic avenue against neurodegenerative pathologies in aging, Alzheimer's disease, and related dementias. A crossover, double-blind, randomized placebo (PBO) controlled trial was conducted to test the safety and efficacy of 8 weeks' active treatment with NR (1 g/day) on cognition and plasma AD biomarkers in older adults with subjective cognitive decline and mild cognitive impairment.
View Article and Find Full Text PDFJACC Adv
December 2024
Department of Neurology, National Cerebral and Cardiovascular Center (NCVC), Suita, Osaka, Japan.
J Spine Surg
December 2024
Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA, USA.
Background: Surgical fusion of the sacroiliac (SI) joint is often performed to manage chronic lower back or buttock pain. When Current Procedural Terminology (CPT) codes were introduced, SI joint fusion procedures were done primarily by orthopaedic surgeons and neurosurgeons. The purpose of this study was to examine the utilization of SI joint fusion CPT codes by physician specialty over time.
View Article and Find Full Text PDFThis study aimed to evaluate the impact of the myelodysplasia-related gene (MRG) as well as additional gene mutations on outcomes in intensively treated patients with -mutated ( ) AML. Targeted DNA sequencing of 263 genes was performed in 568 AML patients (median age: 59 years) entered into the prospective AMLSG 09-09 treatment trial. Most commonly co-mutated genes were (49.
View Article and Find Full Text PDFBMC Cancer
January 2025
Patient Centered Solutions, IQVIA, Reading, UK.
Background: Despite approvals of new first-line immunotherapies for advanced/metastatic gastric cancer/gastroesophageal junction cancer (aGC/GEJC), patients' median survival is around 14 months and their health-related quality of life (HRQoL) is affected by disease-related symptoms and treatment-related side effects. Using a targeted literature review (TLR) and patient interviews, this study identified disease- and treatment-related concepts that are important to patients with aGC/GEJC and their HRQoL.
Methods: A TLR was conducted to identify primary qualitative studies from 2018 to 2021 on patients' experiences with aGC/GEJC.
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