A 7-month-old male infant who presented with bleeding per rectum was evaluated and diagnosed to have ileocolic intussusception on ultrasonography. Despite ultrasonography-guided saline reduction, there was persistence of bleeding per rectum. He was given blood transfusion and referred for Tc-99m pertechnetate scan to rule out ectopic gastric mucosa. The scan was done as per the standard institution protocol and the images revealed a focus of progressively increasing tracer uptake in the right lower abdominal quadrant suggesting the presence of ectopic gastric mucosa. An exploratory laparotomy revealed ileocolic intussusception secondary to Meckel diverticulum acting as a pathologic lead point (PLP). A wedge resection of the intestinal wall containing the diverticulum with suture closure was performed. The presence of Meckel diverticulum and ectopic gastric mucosa was confirmed on subsequent histopathological examination of the specimen. The patient rapidly improved postoperatively and was discharged 9 days after surgery. Bleeding per rectum can be seen in both intussusception and in Meckel diverticulum with ectopic gastric mucosa. Intussusception originating from a Meckel diverticulum as PLP remains a diagnostic challenge because of the overlapping symptoms.The Meckel scan findings, in this case, avoided the further CT scan, angiography, and endoscopy for the diagnosis of the cause of symptoms, sparing not only the time but cost of investigations and unnecessary radiation exposure to the patient.
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http://dx.doi.org/10.1097/RLU.0b013e3181966f88 | DOI Listing |
World J Gastrointest Surg
December 2024
Department of Gastrointestinal Surgery, Meizhou People's Hospital, Meizhou 514031, Guangdong Province, China.
Background: Gastric mucosal heterotopia (GMH) is a rare, typically asymptomatic condition characterized by ectopic gastric mucosa in tissues outside the stomach. However, it can lead to severe complications, including small intestinal perforation. This case report highlights the unique clinical presentation of GMH-induced recurrent small intestinal perforations, which has been rarely documented.
View Article and Find Full Text PDFCirculation
January 2025
Division of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute; and Emory University School of Medicine, Atlanta, GA (L.S.S.).
There is a new awareness of the widespread nature of metabolic dysfunction-associated steatotic liver disease (MASLD) and its connection to cardiovascular disease (CVD). This has catalyzed collaboration between cardiologists, hepatologists, endocrinologists, and the wider multidisciplinary team to address the need for earlier identification of those with MASLD who are at increased risk for CVD. The overlap in the pathophysiologic processes and parallel prevalence of CVD, metabolic syndrome, and MASLD highlight the multisystem consequences of poor cardiovascular-liver-metabolic health.
View Article and Find Full Text PDFAnn Ital Chir
December 2024
Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy; General and Oncologic Surgery, Department of Surgery, Morgagni-Pierantoni Hospital, 47121 Forlì, Italy.
Gastric cancer is a significant health concern worldwide, and its diagnosis and management are of paramount importance. Ectopic pancreas (EP) refers to an embryological abnormality where healthy pancreatic tissue develops without anatomical, vascular, or neural communication with the normal pancreas. We report the case of a patient whose initial endoscopic evaluation suggested early gastric cancer, but computed tomography scan (CT scan) and endoscopic ultrasound (EUS) indicated a locally advanced tumor.
View Article and Find Full Text PDFActa Biochim Biophys Sin (Shanghai)
December 2024
State Key Laboratory of Stress Cell Biology, School of Life Sciences; Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Xiamen 361102, China.
Gastric cancer (GC) is an aggressive tumor type with an intricate pathogenesis and limited therapeutic options. Ubiquitin-specific protease 22 (USP22) is a protein implicated in cell proliferation, metastasis, and tumorigenesis. However, the regulatory mechanisms governing USP22 in GC are still not fully understood.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
October 2024
State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
This study investigated the anti-gastric cancer activity and mechanism of Panacis Quinquefolii Radix(Panax quinquefolium L.), and preliminarily compared the in vivo anti-gastric cancer efficacy of American-imported(JK-AG) and domestically produced(Shandong) Panacis Quinquefolii Radix decoctions(SD-AG). Based on network pharmacology predictions, a LUC-MGC803 cell ectopic gastric cancer nude mouse model was established.
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