Aim: To study the correlation of expression of hTERT, c-myc and Ki-67 with the clinical pathological feature of hepatocellular carcinoma and explore the relationship among the three factors.
Methods: The expressions of hTERT, c-myc and Ki-67 in 37 cancer tissues and 5 normal tissues were assessed by immunohistochemical method.
Results: The positive rates of hTERT, c-myc and Ki-67 in the cancer tissue were higher than those in normal tissues (P<0.05). The expressions of hTERT, c-myc and Ki-67 had nothing to do with age, sex, metastasis and the volume of tumor(P>0.05). With histology stage reducing, the expression of hTERT, c-myc and Ki-67 increased obviously. There is no correlation between hTERT and c-myc(P>0.05), but it's positive correlation between hTERT and Ki-67(P<0.05). With the expression of Ki-67 increasing, hTERT and c-myc increased.
Conclusion: The over-expression of hTERT, c-myc and Ki-67 may play a vital role in the progress of hepatocellular carcinoma developing. The expressions of three factors in hepatocellular carcinoma are closely associated.
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