The data concerning the influence of weak organic acid on microorganisms, particularly yeast Saccharomyces cerevisiae are summarized in the work. The main pathways of weak organic acid arrival into the cell and their metabolism are presented. Responsible mechanisms of microorganism's resistance to the action of weak acids are described. The information regarding the role of H+-ATPase, ABC-transporters and antioxidant enzymes in yeast during acid stress adaptation is given. Special attention is paid to the role of a transport protein Pdr12 and its transcription factor War1 in the response of S. cerevisiae to the stress induced by high concentration of weak organic acid anions in the cell.
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