We analysed scores of elbow dysplasia following the IEWG protocol from the official screening programme of the Allgemeiner Deutscher Rottweiler Club (ADRK). The data set included X-rays from 5100 Rottweiler dogs born between 1995 and 2004. Out of these 5,100 dogs, 46.9% were free from ED, 9.8% showed borderline signs (ED-UG), 31.8% ED-grade 1 (mild ED), 10% ED-grade 2 (moderate ED) und 1.6% ED-grade 3 (severe ED). Male dogs were more often affected by ED-grade 2 and 3 than female dogs. Traits analysed were ED-grade (dogs free from ED and dogs with ED-grades 1 to 3) and borderline ED (ED-UG). Birth year, birth season and inbreeding coefficient were significant for ED-grade. Higher inbreeding coefficients were associated with higher ED scores. ED-UG was significantly influenced by birth year and the interaction of birth year and birth season. A bivariate linear animal model was employed to estimate heritabilities using Residual Maximum Likelihood (REML) for ED-grade and ED-UG. Heritability estimates and their standard errors were 0.387 +/- 0.028 for ED-grade and 0.017 +/- 0.009 for ED-UG. The additive genetic correlation between ED-grade and ED-UG was -0.5. Heritabilities for ED-grade in female and male dogs were 0.350 +/- 0.033 and 0.497 +/- 0.047. We do not recommend use of ED-UG in breeding work because of the low heritability estimate and the negative additive genetic correlation with ED-grade.
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Attach Hum Dev
January 2025
Psychology Department, New School for Social Research, New York, USA.
This study investigated the influence of parents' Adult Attachment Interview (AAI) responses prior to the birth of a first child, on self-reported mental health symptoms of the first-born child in mid-adolescence. The sample comprised 51 first-born children aged 16 years, their mothers and fathers from a low-risk community urban sample, White, British and 70% middle class. AMothers' responses to the AAI were the strongest predictor of their adolescent children's self-reported mental health symptoms.
View Article and Find Full Text PDFTransl Androl Urol
December 2024
University of Washington, Seattle, WA, USA.
Background: Sperm extraction by Microscopic Testicular Sperm Extraction (microTESE) has become the standard of care for sperm retrieval (SR) in men with non-obstructive azoospermia (NOA) but is costly and has a 40-50% chance of failure. Fine needle aspiration mapping (FNAM) can be performed prior to microTESE as a predictor of success to reduce the likelihood of failure to retrieve sperm but there is limited evidence that directly compares these methods. The objective of this study was to compare success rate of SR, pregnancy, and live birth rates in men who underwent upfront microTESE versus FNAM.
View Article and Find Full Text PDFNarra J
December 2024
Department of Midwifery, Politeknik Kesehatan Jayapura, Jayapura, Indonesia.
Papua faces public health challenges as a region with high malaria endemicity and a very high prevalence of stunting. Infectious diseases are one of the risk factors for stunting. The aim of this study was to investigate the effect of early-life malaria exposure on stunting among children in Papua.
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February 2025
Department of Internal Medicine, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
As the second most populated country in Africa, Ethiopia needs public health measures to control diseases that impact its population. The goal of this study is to analyse disease burdens of HBV and HCV, while also highlighting their estimated associated costs for the country. A literature review and a Delphi process reflecting input of Ethiopian experts and the National Viral Hepatitis Technical Working Group were used to complement mathematical modelling to estimate HBV and HCV disease and economic burdens.
View Article and Find Full Text PDFBMC Infect Dis
January 2025
Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte, Minas Gerais, Brazil.
Background: Cirrhosis has been pointed out as a clinical entity that leads to worse clinical prognosis in COVID-19 patients. However, this concept is controversial in the literature. We aimed to evaluate clinical outcomes by comparing patients with cirrhosis to those without cirrhosis in a Brazilian cohort.
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