The paper considers the age-specific features of the clinical course of tropical malaria in children in Tadjikistan. Tropic malaria in children, those of young age in particular, is characterized by the acute onset, polymorphism of clinical manifestations, high fever of mainly abnormal type, and hepatosplenomegaly. Tropical malaria takes the most severe course in children of the first three years. The severity of the disease is due to the development of the toxic syndrome, cerebral disorders, and hemolytic anemia. An association has been seen between the onset of etiotropic treatment and the degree of tropic malaria: the earlier antimalaria therapy is initiated, the milder the disease is.
Download full-text PDF |
Source |
---|
PLoS Med
January 2025
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
In this Perspective article, Lorenz von Seidlein outlines the promise of two malaria vaccines, and discusses some of the considerations for their roll out.
View Article and Find Full Text PDFJ Travel Med
January 2025
Infectious Diseases Unit, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel.
Background: Febrile illness in returned travelers presents a diagnostic challenge in non-endemic settings. Chat generative pretrained transformer (ChatGPT) has the potential to assist in medical tasks, yet its diagnostic performance in clinical settings has rarely been evaluated. We conducted a preliminary validation assessment of ChatGPT-4o's performance in the workup of fever in returning travelers.
View Article and Find Full Text PDFPLOS Glob Public Health
January 2025
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Background: The countries within the Greater Mekong Region of Southeast Asia have pledged to eliminate malaria by 2030. Elimination of Plasmodium vivax malaria is challenging as it requires radical cure to prevent relapse. Understanding and facilitating adherence to primaquine radical cure regimens is necessary for malaria elimination.
View Article and Find Full Text PDFParasit Vectors
January 2025
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Ramat, Thailand.
Background: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is proposed for mosquito species identification. The absence of public repositories sharing mass spectra and open-source data analysis pipelines for fingerprint matching to mosquito species limits the widespread use of this technology. The objective of this study was to develop a free open-source data analysis pipeline for Anopheles species identification with MALDI-TOF MS.
View Article and Find Full Text PDFBMC Infect Dis
January 2025
Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya.
Background: To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. Recent advances in next-generation sequencing (NGS) technologies have enabled the tracking of drug-resistant malaria parasites.
Methods: In this study, we used Targeted Amplicon Deep Sequencing (TADS) to characterise the genetic diversity of the Pfk13, Pfdhfr, Pfdhps, and Pfmdr1 genes among primary school-going children in 15 counties in Kenya (Bungoma, Busia, Homa Bay, Migori, Kakamega, Kilifi, Kirinyaga, Kisii, Kisumu, Kwale, Siaya, Tana River, Turkana, Vihiga and West Pokot).
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!