Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757932 | PMC |
| http://dx.doi.org/10.1002/anie.200900112 | DOI Listing |
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